子痫前期重度患者新生儿脐血网膜素表达水平与临床意义  

Omentin expression level in neonatal umbilical cord of patients with severe preeclampsia and its and clinical significance

作　　者：周萍[1] 高雪梅[1] 王瀚[1] 孟红娟[1] ZHOU Ping;GAO Xue-Mei;WANG Han;MENG Hong-juan(Department of Obstetrics,Wuhan No.1 Hospital,Wuhan 430022,Hubei,China)

机构地区：[1]湖北省武汉市第一医院妇产科,湖北武汉430022

出　　处：《海南医学院学报》2018年第13期1264-1267,共4页Journal of Hainan Medical University

基　　金：武汉市卫计委医学科研项目(WX16C34)~~

摘　　要：目的:研究子痫前期重度患者新生儿脐血网膜素表达水平及其与母体内皮损伤、胎盘滋养细胞侵袭的相关性。方法:选择2015年11月~2017年10月期间在武汉市第一医院诊断为重度子痫前期并分娩的受试者作为PE组、同期在武汉市第一医院分娩的健康受试者作为对照组,测定新生儿脐血中网膜素的表达水平、母体血中内皮损伤指标的含量、胎盘中侵袭基因的表达量。结果:PE组新生儿脐血网膜素的蛋白表达量、母体血中VEGF、PLGF的含量以及胎盘中OPN、MMP2、MMP9的mRNA表达量均显著低于对照组,母体血中IFI16、ET-1、sEng、sFlt-1的含量以及胎盘中Gadd45α、E-cadherin的mRNA表达量均显著高于对照组;网膜素高表达患者的母体血中IFI16、ET-1、sEng、sFlt-1的含量以及胎盘中Gadd45α、E-cadherin的mRNA表达量显著低于网膜素低表达患者,母体血中VEGF、PLGF的含量以及胎盘中OPN、MMP2、MMP9的mRNA表达量均显著高于网膜素低表达患者。结论:子痫前期重度患者新生儿脐血网膜素的低表达与母体内皮损伤、胎盘滋养细胞侵袭不足密切相关。Objective： To study the omentin expression level in neonatal umbilical cord of patients with severe preeclampsia and its correlation with maternal endothelial injury and placental trophoblast invasion. Methods： The subjects who were diagnosed with severe preeclampsia and gave birth in Wuhan No.1 Hospital between November 2015 and October 2017 were selected as the PE group, healthy subjects who gave birth in Wuhan No.1 Hospital during the same period were selected as control group, and the omentin expression in neonatal umbilical cord, endothelial injury index contents in maternal blood and invasion gene expression in placenta were determined. Results： The omentin expression in neonatal umbilical cord, VEGF and PLGF contents in maternal blood as well as OPN, MMP2 and MMP9 mRNA expression in placenta of PE group were significantly （ P 〈0.05） lower than those of control group whereas IFI16, ET-1, sEng and sFlt-1 contents in maternal blood as well as Gadd45α and E-cadherin mRNA expression in placenta were significantly （ P 〈0.05） higher than those of control group; IFI16, ET-1, sEng and sFlt-1 contents in maternal blood as well as Gadd45α and E-cadherin mRNA expression in placenta of patients with high omentin expression were significantly （ P 〈0.05） lower than those of patients with low omentin expression whereas VEGF and PLGF contents in maternal blood as well as OPN, MMP2 and MMP9 mRNA expression in placenta were significantly （ P 〈0.05） higher than those of patients with low omentin expression. Conclusion： The low expression of omentin in neonatal umbilical cord of patients with severe preeclampsia is closely related to the maternal endothelial injury and insufficient placental trophoblast invasion.

关 键 词：子痫前期 网膜素 内皮损伤 滋养细胞侵袭 

分 类 号：R714.245[医药卫生—妇产科学]