附加艾司西酞普兰治疗对男性精神分裂症认知损害改善的分析  

Analysis of Cognitive Impairment in Male Schizophrenia Treated with Additional Escitalopram

作　　者：杨筱慧 YANG Xiao-hui(Department of Psychiatry,Psychiatric Hospital of Mudan District,Heze,Shandong Province,274000 China)

机构地区：[1]菏泽市牡丹区精神病医院精神科,山东菏泽274000

出　　处：《中外医疗》2018年第14期115-116,119,共3页China & Foreign Medical Treatment

摘　　要：目的分析附加艾司西酞普兰治疗对男性精神分裂症认知损害的改善作用。方法便利选取2015年8月—2017年11月该院收治的80例男性精神分裂症患者作为研究对象,采用利培酮附加艾司西酞普兰进行治疗,为实验组,同期招募80名健康男性作为对照组,分析实验组患者的治疗效果,并与对照组的认识功能评分进行比较。结果实验组患者治疗前后阳性症状与阴性症状评分比较差异无统计学意义(t=0.000 0,P>0.05),SANS评分有统计学意义(t=2.044 5,P<0.05);实验组患者治疗后各项RBANS评分与治疗前比较差异有统计学意义(P<0.05),其中语言功能评分达(93.51±10.43)分,与对照组比较差异无统计学意义(P>0.05,t=0.224 9)。结论附加艾司西酞普兰治疗男性精神分裂能在一定程度上改善其精神症状,并有效缓解其认知功能损害,其中对语言功能的改善最为明显,用药后其语言功能趋近于健康人。Objective This paper tries to analyze the effect of additional escitalopram on cognitive impairment in male schizophrenia. Methods 80 male patients with schizophrenia who were admitted conveniently to this hospital from August2015 to November 2017 were selected as subjects and treated with risperidone and escitalopram for the experimental group.During the same period, 80 healthy men were recruited as control group. The treatment effect of the experimental group and the control group was compared of the cognitive function score. Results The positive and negative symptom scores of patients in the experimental group before and after treatment were not statistically significant（t =0.000 0,P〈0.05）, and the SANS score was statistically significant（t =2.044 5,P〈0.05）; the patients in the experimental group after treatment, the RBANS score was statistically significant compared with that before treatment（P〈0.05）, and the language function score was（93.51±10.43） points, which was not statistically significant compared with the control group（t=0.224 9,P〈0.05）. Conclusion The addition of escitalopram in the treatment of male schizophrenia can, to a certain extent, improve the psychiatric symptoms and effectively relieve the cognitive impairment. Among them, the improvement of language function is most obvious. After the administration of escitalopram, the language function tends to be closer to healthy people.

关 键 词：附加艾司西酞普兰 男性精神分裂症 认知损害 

分 类 号：R4[医药卫生—临床医学]