膜生物材料及在组织工程中的应用:“引导膜再生理论”的展望  

Membrane biomaterials in tissue engineering:an outlook on guided membrane regeneration theory

作　　者：李栎 张恒[2] 唐历波 Li Li;Zhang Heng;Tang Li-bo(School of Basic Medicine and Life Sciences,Hainan Medical University,Haikou 571199,Hainan Province,China;Panjin Municipal Library,Panjin 124000,Liaoning Province,China)

机构地区：[1]海南医学院基础医学与生命科学学院,海南省海口市571199 [2]盘锦市图书馆,辽宁省盘锦市124000

出　　处：《中国组织工程研究》2018年第22期3595-3601,共7页Chinese Journal of Tissue Engineering Research

基　　金：海南省自然科学基金(813190)~~

摘　　要：背景:膜生物材料是一大类与组织工程及再生医学密切相关的基础材料,在组织构建和器官再生领域得到了广泛应用。目的:综述各种成膜材料及其在组织再生中应用。方法:利用计算机检索PubMed及中国期刊全文数据库2002年1月至2017年3月有关膜生物材料的论文133篇,英文检索词"membrane biomaterial,scaffold,tissue engineering,regeneration medicine",中文检索词为"膜生物材料,支架,组织工程,再生医学"。通过归纳整理最后选定45篇文献进行综述。结果与结论:按膜生物材料的来源可分为天然脱细胞基质膜、有机高分子膜及人工合成大分子膜。天然有机高分子膜利用天然有机高分子材料经化学或物理处理后形成膜,包括蛋白质类与多糖类。人工合成的有机大分子种类繁多,主要有聚乳酸和聚乙醇酸及两者共聚物、聚乙烯醇、聚己内酯、聚羟基丁酸等。目前,围绕着膜生物材料在组织工程中的应用,在基础领域中逐渐形成一个膜再生诱导理论,已在骨组织诱导再生实践中得到广泛应用。今后需要进一步完善"引导膜再生理论"并在其他组织再生中推广应用。BACKGROUND： Membrane biomaterials are a kind of basic materials closely related to tissue engineering and regenerative medicine, which have been widely used in tissue construction and organ regeneration. OBJECTIVE： To review a variety of film forming materials and their application in tissue regeneration. METHODS： Pub Med and Chinese Journal Full-Text Database were searched by computer for articles concerning membrane biomaterials published from January 2002 to March 2017. The key words were ＂membrane biomaterial, scaffold, tissue engineering, regeneration medicine＂ in English and Chinese, respectively. Initially 133 articles were retrieved, and finally 45 articles were included in result analysis. RESULTS AND CONCLUSION： Membrane biomaterials from different origins can be divided into naturalacellular matrix membrane, organic polymer membrane and synthetic macromolecular membrane. Natural organic polymer membranes, including proteins and polysaccharides, have been prepared by natural organic polymer materials using chemical or physical treatments. Synthetic organic macromolecules are various, mainly including polylactic acid, polyglycolic acid and their copolymers, polyvinyl alcohol, polycaprolactone, polyhydroxybutyrate. Until now, a membrane regeneration theory gradually forms in the basic field based on the use of membrane biomaterials in tissue engineering, which has been widely used in the bone induction. Extensive research is warranted to improve the guided membrane regeneration theory and popularize its application in tissue regeneration.

关 键 词：羊膜 胶原 壳聚糖 组织工程 再生医学 天然脱细胞基质 纤维素膜 医学组织工程 海南省自然科学基金 生物材料 

分 类 号：R318[医药卫生—生物医学工程]