新疆地区维吾尔族、汉族、哈萨克族ABO血型与冠心病相关性分析  

Correlation between ABO blood type and coronary heart disease in nationality of Uygur,Han and Kazakh in Xinjiang

作　　者：朱婷文 李丞[2] 帕它木.莫合买提 孙娟[4] 赵利[4] 宋小川[1] ZHU Tingwen,LI Cheng,PATAMU Mohemaiti,SUN Juan,ZHAOL Li,SONG Xiaochuan(ZHU Tingwen ＊, LI Cheng, PATAMU Mohemaiti, SUN Juan, ZHAOL Li, SONG Xiaochuan.＊ Department of Blood Transfusion, Information Statistics Centre, First Affiliated Hospital of Xinjiang Medical University, Xinjiang, Urumqi 830054,China)

机构地区：[1]新疆医科大学第一附属医院输血科,乌鲁木齐830054 [2]新疆医科大学第一附属医院信息统计中心,乌鲁木齐830054 [3]新疆医科大学公共卫生学院劳动卫生与环境卫生教研室,830011 [4]新疆医科大学第一附属医院心内科,乌鲁木齐830054

出　　处：《疑难病杂志》2018年第7期654-657,662,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：国家重点基础研究发展计划(973计划)项目(2012CB722421)

摘　　要：目的探究新疆地区维吾尔族、汉族、哈萨克族冠心病与ABO血型之间的相关性及其可能机制。方法选取2014年1月—2017年12月新疆医科大学第一附属医院心内科住院治疗并明确诊断为冠心病的患者1 740例作为冠心病组,并选择同期在医院其他科室就诊的患者1 536例为对照组,均未合并心脑血管疾病、病史资料完整,与冠心病组性别、年龄、民族、居住地完全匹配,2组患者均在医院实验室进行血型鉴定试验及血脂水平检测,包括总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、非高密度脂蛋白胆固醇(NHDL-C)。对ABO血型与冠心病之间的相关性及其机制进行探索。结果冠心病组冠心病家族史、吸烟史、既往史(合并高血压和/或糖尿病)比例高于对照组,O血型人群比例少于对照组,而A血型、B血型比例均多于对照组(P均<0.05);冠心病组ABO血型分布在维吾尔族和汉族患者中为B>A>0>AB,而在哈萨克族中则为A>O>B>AB。ABO血型与冠心病的关系分析显示,非0血型者均较O血型者更易患冠心病;冠心病发生的血型单因素和多因素Logistic回归分析均显示,B血型是冠心病的危险因素;TC、LDL-C、NHDL-C等作为中介因素介导着ABO血型与冠心病之间的关系。结论新疆地区维吾尔族、汉族、哈萨克族人群ABO血型与冠心病患病率之间存在高度的相关性。B型血是维吾尔族和汉族冠心病发生的危险因素,A型血是哈萨克族冠心病发生的危险因素。Objective To investigate the correlation between ABO blood type and coronary heart disease in Uygur,Han and Kazakh in Xinjiang. Methods One thousand seven hundred and forty patients who were diagnosed as coronary heart disease in the heart center of the first affiliated Hospital of Xinjiang Medical University from January 2014 to December 2017 were selected as coronary heart disease group. Meanwhile,1 536 patients who were treated in other departments of the same hospital during the same period without cardiovascular and cerebrovascular diseases and complete medical history data were selected as the control group. Coronary heart disease group and control group were tested in blood transfusion laboratory of our hospital and recorded by computer. A retrospective case control study was conducted to explore the relationship between ABO blood type and coronary heart disease and its mechanism. Results Family history of coronary heart disease, smoking history and past history （hypertension and /or diabetes） were higher in coronary heart disease group than those in control group. The population of O blood group was less than that of the control group. The number of patients with type A, B and AB were more than those of the control group （ P 〈0.05）. In coronary heart disease group,the distribution of ABO blood type was B〉A〉O〉AB in Uygur and Han nationality,but A〉O〉B〉AB in Kazakh nationality.Analysis of the relationship between ABO blood group and coronary heart disease showed that patients with non O blood type were more susceptible to coronary heart disease than those with O blood type. Univariate and multivariate logistic regression analysis showed that B blood type was a risk factor for coronary heart disease. The relationship between ABO blood type and coronary heart disease is mediated by total cholesterol,low density lipoprotein and non-high density lipoprotein as intermediary factors. Conclusion There is a high correlation between the ABO blood type in Uygur, Han and Kazakh populations and

关 键 词：ABO血型 冠心病 汉族 维吾尔族 哈萨克族 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]