改良微创置管吸引术对脑出血患者骨桥蛋白及水肿带宽度变化的影响  

The effect of modified minimal trauma installed tube on serum osteopontin levels and edema band width in patients with cerebral hemorrhage

作　　者：肖波[1] 石碑田 徐礼林[1] 林宁[1] XIAO Bo,SHI Beitian,XU Lilin,LIN Ning(Department of Neurosurgery, the First People ＇ s Hospital of Chuzhou City,Chuzhou 239000,China)

机构地区：[1]安徽省滁州市第一人民医院神经外科,239000

出　　处：《疑难病杂志》2018年第7期671-674,共4页Chinese Journal of Difficult and Complicated Cases

摘　　要：目的观察改良微创置管吸引术对脑出血患者骨桥蛋白及水肿带宽度变化的影响。方法选取2014年8月—2017年5月安徽省滁州市第一人民医院神经外科收治的脑出血患者102例作为研究对象,随机数字表法分为2组,每组51例。传统组进行常规治疗配合传统微创置管吸引,改良组则根据患者自身情况确定血肿抽吸量。对比2组治疗效果(NIHSS、GCS及FMA评分)、骨桥蛋白及水肿带宽度差异。结果治疗前,2组NIHSS、GCS、FMA评分,骨桥蛋白及水肿带宽度组间比较差异无统计学意义(P>0.05)。治疗后,2组NIHSS评分、骨桥蛋白水平及水肿带宽度明显低于治疗前,GCS评分、FMA评分明显高于治疗前(P<0.05),其中,改良组NIHSS评分、骨桥蛋白水平、第8天水肿带宽度明显低于传统组(t/P=3.307/0.001,2.181/0.032,3.621/0.000);GCS评分、FMA上肢评分、FMA下肢评分均明显高于传统组(t/P=2.491/0.015,2.695/0.009,3.555/0.001)。结论改良微创置管吸引术通过降低患者体内骨桥蛋白水平,改善水肿带宽度,抑制脑部缺血再灌注损伤,发挥恢复神经功能的效果。Objective To investigate the effect of modified minimal trauma installed tube on serum osteopontin levels and edema band width in patients with cerebral hemorrhage. Methods One hundred and two cases of patients with cerebral hemorrhage were admitted to our hospital from August 2014 to May 2017 were selected as objects and randomly divided into two groups,with 51 cases in each group. The traditional group received conventional therapy combined with minimal trauma installed tube surgery,while the modified group was implemented modified minimal trauma installed tube. The clinical effect （including NIHSS score, GCS score, FMA score） and serum osteopontin levels and edema band width between two groups were compared. Results The NIHSS score,GCS score,FMA score,serum osteopontin levels and edema band width between two groups were without significant differences（ P 〉0.05）. The NIHSS score, serum osteopontin levels and edema band width of the two groups were much lower after treatment than those before treatment（ P 〉0.05）, The GCS score, FMA score of the two groups were much higher after treatment than those before treatment（ P 〈0.05）. The NIHSS score, serum osteopontin levels and edema band width of the modified group were much lower than those in traditional group（ t/P =3.307/0.001,2.181/0.032,3.621/0.000）. The GCS score FMA score of upper limb, FMA score of lower limb of the modified group were much higher after treatment than in traditional group （ t/P =2.491/0.015,2.695/0.009,3.555/0.001）. Conclusion Modified minimal trauma installed tube could reduce the osteopontin levels and improve the width of edema in patients with intracerebral hematoma, which can inhibit cerebral ischemia reperfusion injury, and restore nerve function.

关 键 词：改良微创置管吸引术 脑出血 骨桥蛋白 水肿带宽度 

分 类 号：R651.12[医药卫生—外科学]