舒肝解郁胶囊对溃疡性结肠炎患者焦虑、抑郁状态的影响  

The effect of Shuganjieyu capsule on anxiety and depression in patients with ulcerative colitis

作　　者：胡义亭[1] 苏少慧[1] 张建[1] 贾桂丛 侯洪涛[1] 白云[1] 王玉珍[1] HU Yiting, SU Shaohui, ZHANG Jian, JIA Guicong, HOU Hongtao, BAI Yun, WANG Yuzhen(Department of Gastroenterology, Hebei People＇s Hospital,Shijiazhuang 050051,China)

机构地区：[1]河北省人民医院消化内科,石家庄050051

出　　处：《疑难病杂志》2018年第7期693-696,共4页Chinese Journal of Difficult and Complicated Cases

基　　金：河北省医学科学研究重点课题计划(20160067)

摘　　要：目的探讨舒肝解郁胶囊对溃疡性结肠炎患者焦虑、抑郁状态的影响。方法选择2015年4月—2016年3月河北省人民医院消化内科收治溃疡性结肠炎患者80例,按照随机数字表法随机分为观察组和对照组,每组40例。2组给予常规基础治疗,对照组给予口服美沙拉嗪,1.0 g/次,4次/d;观察组在对照组治疗基础上,给予舒肝解郁胶囊口服,2粒/次,2次/d。2组治疗时间均为8周。评价并比较2组临床疗效,检测粪便钙卫蛋白、血清C反应蛋白(CRP)、红细胞沉降率(ESR)变化情况;检测心率变异性(HRV)变化情况,包括低频值(LF)、高频值(HF)、LF/HF值;应用焦虑自评量表(SAS)及抑郁自评量表(SDS)进行评分。结果观察组治疗总有效率明显高于对照组(95.0%vs 80.0%),差异有统计学意义(χ~2=4.114,P<0.05)。2组治疗后粪便钙卫蛋白、血清CRP及ESR水平均明显低于治疗前(对照组:t=52.814、14.443、10.111,P均<0.01,观察组:t=59.294、25.291、53.815,P均<0.01),且观察组治疗后优于对照组(t=50.007、23.706,31.184,P均<0.01)。观察组治疗后HF明显高于治疗前,LF、LF/HF明显低于治疗前(P<0.01),且优于对照组(t=13.174、-6.507、-5.166,P<0.01)。观察组治疗后SAS、SDS评分明显低于治疗前(P<0.01),且优于对照组(t=18.215、3.180,P<0.01)。结论溃疡性结肠炎给予基础治疗的同时给予舒肝解郁胶囊,能够显著改善患者的心理状态、自主神经功能障碍,并减轻机体炎性反应。Objective To explore the effect of Shuganjieyu capsule on anxiety and depression in patients with ulcerative colitis. Methods Randomly selected 80 patients with ulcerative colitis, who were randomly divided into observation group and control group, with 40 cases in each group. The control group received regular treatment, oral methalazine, 1.0 g/time,4 times/day. The observation group was treated on the basis of the control group, and given ShuGanJieYu capsule,2 pills/time,2 times/day. Both groups were treated for 8 weeks. The clinical efficacy of the two groups were evaluated and compared.Before and after treatment, the calprotectin, CRP, ESR, HRV, SAS and SDS scores in the two groups were observed and compared. Results The total effective rate was significantly higher in the observation group than in the control group（95.0% vs 80.0%）,and the difference was statistically significant（P〈0. 05）. After treatment, calprotectin, CRP, ESR were significantly lower than before treatment in both of the two groups（P〈0. 01）. The observation group was more effective.After treatment,HF was significantly higher in observation group than before treatment and control group, LF, LF/HF was significantly lower than before treatment and control group（P〈0. 01）. After treatment, SAS and SDS scores were significantly lower in observation group than before treatment and control group, the difference was statistically significant（P〈0. 01）.Conclusion For patients with ulcerative colitis, basic treatment should be carried out and psychological treatment should be performed, which could significantly improve the patient＇s mental state, autonomic nerve dysfunction, and reduce the level of inflammation of the body.

关 键 词：溃疡性结肠炎 焦虑 抑郁 舒肝解郁胶囊 心理治疗 

分 类 号：R259[医药卫生—中西医结合]