带状疱疹的临床特征及与他汀类药物关系的回顾性研究  

Clinical Features of Herpes Zoster and Its Correlation with Statins Usage

作　　者：袁媛[1] 黄文祥[1] 贾蓓[1] YUAN Yuan;HUANG Wen-xiang;JIA Bei(Department of Infectious Diseases,the First Affiliated Hospital of Chongqing Medical University/Key Laboratory of Infectious and Parasitic Diseases in Chongqing,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院感染科重庆市传染病寄生虫病学重点实验室,重庆市400016

出　　处：《中国全科医学》2018年第21期2587-2591,共5页Chinese General Practice

摘　　要：背景带状疱疹作为常见病毒感染性疾病,在体内病毒重新复活时可引起皮肤丘疹水疱,并可伴有神经痛、带状疱疹眼病、继发感染等,严重影响患者生活质量。他汀类药物作为调脂药物,在临床中应用广泛。目前已有研究证实带状疱疹的发生与他汀类药物的使用存在联系。目的分析带状疱疹的临床特征,探讨带状疱疹发病与他汀类药物使用的关系。方法收集2014年11月—2016年11月于重庆医科大学附属第一医院住院并诊断为带状疱疹患者731例作为带状疱疹组,同期收集非带状疱疹患者731例作为对照组。收集研究对象的一般资料,包括性别、年龄、吸烟史、饮酒史、体质指数(BMI)、血脂水平、合并症、他汀类药物和抗血小板凝集药物使用情况、脂肪肝发生情况。分析带状疱疹患者的性别、年龄分布,带状疱疹与烟酒史、BMI、血脂水平、合并症、他汀类药物和抗血小板凝集药物使用情况的关系。将带状疱疹组根据患者年龄分为≤30岁亚组49例、31~60岁亚组261例、>60岁亚组421例,比较各亚组带状疱疹发病的特点。结果带状疱疹组他汀类药物使用率高于对照组(P<0.05)。带状疱疹组患者中,有合并症患者446例(61.0%),其中存在2种及以上合并症228例(51.1%)。常见的合并症是高血压242例(54.3%)及糖尿病134例(30.0%)。不同年龄亚组患者带状疱疹发生率比较,差异有统计学意义(P<0.05)。>60岁亚组合并高血压、除外高血压的其他心血管疾病、脑卒中发生率、他汀类药物使用率高于≤60岁亚组(P<0.05);31~60岁亚组合并糖尿病发生率高于≤30岁亚组(P<0.05);≤30岁亚组合并肿瘤发生率高于31~60岁亚组和>60岁亚组(P<0.05);31~60岁亚组合并结缔组织病发生率低于≤30岁亚组,但高于>60岁亚组,≤30岁亚组合并结缔组织病发生率高于>60岁亚组(P<0.05)。结论带状疱疹的发生可能与年龄增长及服用他汀类药物�Background Herpes zoster is a common infectious disease caused by reactivation of varicella zoster virus.This disease may lead to papule blister,and may be accompanied by neuralgia,herpes zoster ophthalmicus,secondary infection,etc,seriously impairing the patient＇s quality of life.Statins are widely used in clinical practice as a lipid-regulating drug.Several studies have confirmed that herpes zoster is associated with the use of statins.Objective To analyze the clinical characteristics of herpes zoster and to explore the relationship between herpes zoster and the use of statins.Methods The enrolled 1 462 inpatients were all from the First Affiliated Hospital of Chongqing Medical University from November 2014 to November 2016,including 731 with herpes zoster（herpes zoster group）,and 731 without herpes zoster（control group）.Demographic and clinical data,including gender,age,smoking history,drinking history,body mass index（BMI）,lipid levels,comorbidities,and use of statins and antiplatelet aggregation drugs were collected.The prevalence of herpes zoster by gender and age,the relationship of herpes zoster with smoking and drinking history,BMI,lipid level,comorbidities,use of statins and antiplatelet agglutination drugs were analyzed.The herpes zoster patients were divided into ≤ 30-year-old subgroup（49 cases）,31-60-year-old subgroup（261 cases）,and 〉60-year-old subgroup（421 cases）,then their characteristics were compared.Results The use rate of statins in herpes zoster group was higher than that of the control group（P〈0.05）.Amongthe herpes zoster patients,there were 446（61.0%） with comorbidities,including 228（51.1%） with multicomorbidities;the most common comorbidities were hypertension[242 cases（54.3%）]and diabetes[134 cases（30.0%）].The prevalence of herpes zoster varied significantly by age subgroups（P〈0.05）.Herpes zoster patients in 〉 60-year-old subgroup had higher use rate of statins,higher prevalence of hypertension cardiovascular diseases except hype

关 键 词：带状疱疹 临床特征 他汀类药物 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]