时间控制/pH依赖型盐酸黄连素结肠给药系统的控释性能  

Controlled Release Properties of a Time-controlled/pH-dependent Colonic Drug Delivery System for Berberine Hydrochloride

作　　者：毕玉水 BI Yushui(School of Chemistry and Pharmaceutical Engineering,Taishan Medical Univershy,Tai＇an 271016)

机构地区：[1]泰山医学院化学与制药工程学院,泰安271016

出　　处：《材料导报》2018年第12期1973-1977,共5页Materials Reports

基　　金：山东省自然科学基金(ZR2015EL010);山东省中医药管理局科技发展计划(2015-252)

摘　　要：以全硅MCM-41介孔分子筛为主体,以盐酸黄连素(BH)药物分子为客体,利用天然高分子海藻酸钠(SA)和壳聚糖(CS)为包覆材料,通过振荡吸附-浸提法制备了时间控制/pH依赖型BH/MCM-41/CS-SA结肠给药系统。利用XRD、SEM、BET、FTIR等技术对其理化性质进行了表征,并采用分光光度法对其载药和体外释药性能进行了评价。结果表明,BH/MCM-41/CS-SA的载药率为23.5%,载药后未破坏MCM-41的介孔结构。体外释放结果表明,相较BH/MCM-41,BH/MCM-41/CS-SA具有显著的时滞/pH依赖敏感释药特征,具备较好的结肠靶向给药性能,还具有长效控缓释放效果。The present work proposed and successfully prepared a time-controlled/pH dependent colonic drug delivery system for berberine hydrochloride（BH）,i.e.BH/MCM-41/CS-SA,by a combinative method of oscillation absorption and dip-coating,using MCM-41 mesoporous silica molecular sieve as the main body,BH drug molecules as the object,natural polymers — sodium alginate（SA）and chitosan（CS）as the coating materials.The physical and chemical properties of BH/MCM-41/CS-SA were characterized by XRD,SEM,BET and FTIR,and its drug loading and release properties in vitro were evaluated by spectrophotometry.The results showed that the drug loading rate of BH/MCM-41/CS-SA was 23.5%,and the mesoporous structure of MCM-41 was not destroyed after loading.In vitro results indicated the conspicuous time-delay/pH dependent drug release characteristic of BH/MCM-41/CS-SA compared with BH/MCM-41,which displays both favorable colon specific drug delivery performance and long-term controlled release efficacy.

关 键 词：盐酸黄连素 MCM-41 海藻酸钠 壳聚糖 控制释放 

分 类 号：TB321[一般工业技术—材料科学与工程]