活化素受体样激酶1及其在血管生成中的作用  

Activin receptor-like kinase 1 and its roles in angiogenesis

作　　者：林比霖 徐方云[2] 黄永红[2] LIN Bi-lin;XU Fang-yun;HUANG Yong-hong(Second Clinical Medical College;Department of Pathophysiolog,Basic Medical of Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学第二临床医学院,江西南昌330006 [2]南昌大学基础医学院病理生理学教研室,江西南昌330006

出　　处：《中国病理生理杂志》2018年第6期1147-1152,共6页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81660163);江西省自然科学基金资助项目(No.20161BAB205205);江西省卫生厅中医药课题资助项目(No.2016A059)

摘　　要：血管生成是指新的血管从已存在的毛细血管网生成的过程,受血管生成促进因子和抑制因子的严格调控。通常,血管生成发生于胚胎和出生后早期血管的发育过程中,除女性生理周期和伤口愈合等过程外,在成年阶段血管生成已处于静息状态。但是,在发生某些疾病如肿瘤、糖尿病视网膜病变、心血管疾病及类风湿性关节炎[1-2]时,血管生成过程被异常激活。Activin receptor-like kinase（ ALK） 1 is a transforming growth factor-β/bone morphogenetic proteins superfamily type I receptor,predominantly expressed in active endothelial cells. ALK1 has been shown to play a pivotal role in regulating angiogenesis,which is involved in vascular formation during embryonic and early postnatal development and angiogenesis-related diseases,such as cardiovascular disorders and tumor. Understanding the exact function of ALK1 in angiogenesis will provide theoretical basis for anti-angiogenic strategy of ALK1 inhibition. In the present study,we briefly recapitulate ALK1 signaling pathway and its role in blood vessel formation and pathological neovascularization.

关 键 词：活化素受体样激酶1 血管生成 血管发育 

分 类 号：R331.3[医药卫生—人体生理学] R363[医药卫生—基础医学]