不同工龄的核从业人员血清早衰细胞因子BALP以及TRACP-5b的表达分析  

Expressions of serum BALP and TRACP-5b in personnel involved in nuclear industry of different working ages

作　　者：章莉 朱军[1] 贺再清 陈敬[1] 周静秋[1] 陈丽娟[1] Zhang Li;Zhu Jun;He Zai qing;Chen Jing;Zhou Jing qiu;Chen Li juan(Nuclear Industry 416 Hospital,Sichuan Chengdu 610051)

机构地区：[1]核工业四一六医院核应急分队,四川成都610051

出　　处：《四川生理科学杂志》2018年第2期86-88,共3页Sichuan Journal of Physiological Sciences

基　　金：四川省卫生计生委科研课题(编号:130570)

摘　　要：目的:比较不同工龄组的核从业人员血清早衰细胞因子:骨特异性碱性磷酸酶(Serum bone alkaline phosphates,BALP),抗酒石酸酸性磷酸酶-5b(Tartrate-resistant acid phosphatase isoform-5b,TRACP-5b)的表达情况。方法:将2015年9月至2016年2月,在我院体检的核从业人员216例根据工龄随机分成5组,其中工龄0~3年组36例,工龄3~8年组37例,工龄8~15年组63例,工龄15~25年组56例,工龄>25年组24例。同时选取正常对照组41例,早晨6:00~8:00采集空腹静脉血,采用酶联免疫吸附法(Enzyme linked immunosorbent assay,ELISA)测定血清BAlP和TRACP-5b的水平。结果:BALP的表达水平随工龄增长而降低,在"15~25年工龄组"表达最低;TRACP-5b表达水平随工龄增长而增高,在"15~25年工龄组"表达最高;"15~25年"工龄组的核从业人员,血清早衰细胞因子BALP以及TRACP-5b的表达与其他工龄组存在显著差异。结论:核从业人员的"15~25年"工龄期是早衰的易发时期,血清BALP以及TRACP-5b可作为早衰发生的预警指标,据此变化制定针对性的职业照护方案,对核从业人员的实施更完备的职业防护。Objective：To compare the expressions of serum bone alkaline phosphates（BAlP）and tartrate-resistant acid phosphatase isoform-5 b（tracp-5 b）in the personnel involved in the nuclear industry in different working ages.Methods：In total216 workers employed in the nuclear industry were divided into five groups according to their working ages.Expressions of serum BALP and tracp-5 bwere measured by enzyme-linked immunosorbent assay（ELISA）.Results：The expression of BAP decreased with the increase of working age,and the lowest expression was in the 15-25 years working group.The expression of tracp-5 bwas increased with the increase of working age,and the expression was highest in＂15-25 years＂of working age group.There were significant differences in the expression of the serum progeria cytokines BAlP and the expression of tracp-5 bbetween the ＂15-25 years＂ working age group and other working age groups.Conclusions：The personnel involved in the nuclear industry with＂15 ~ 25 years＂working ages are susceptible to premature aging.

关 键 词：核从业人员 早衰 BALP TRACP-5b 

分 类 号：R135[医药卫生—劳动卫生]