老年2型糖尿病伴周围神经病变患者IL-1β、HCY、Cys-C、HbA1c水平研究  

Study on the correlation between IL-1β,Hcy,Cys-C and HbA1c levels and senile type 2 diabetic peripheral neuropathy

作　　者：罗一青[1] 李娜[1] 圈启芳[1] 余平 周星利[1] 刘玲玲[1] LUO Yiqing;LI Na;QUAN Qifang;YU Ping;ZHOU Xingli;LIU Lingling(Affiliated Hospital of Qinghai University,Xining,Qinghai 810001,China)

机构地区：[1]青海大学附属医院,西宁810001

出　　处：《国际检验医学杂志》2018年第12期1425-1428,共4页International Journal of Laboratory Medicine

摘　　要：目的探究白细胞介素-1β(IL-1β)、同型半胱氨酸(HCY)、胱抑素C(Cys-C)、糖化血红蛋白(HbA1c)水平变化与老年2型糖尿病周围神经病变的相关性。方法选取2014年6月至2016年12月该院收治的老年2型糖尿病104例作为研究组,将其中伴有周围神经病变的52例患者分为研究A组,单纯2型糖尿病患者52例分为研究B组,另抽取52例同期健康体检者作为对照组。应用免疫比浊法测定Cys-C水平,酶联免疫试验测定血清HCY、IL-1β水平,高效液相色谱法测定HbA1c水平,比较各组IL-1β、HCY、Cys-C、HbA1c水平,并分析其与老年2型糖尿病周围神经病变的关系。结果单因素方差分析可知,3组IL-1β、HCY、Cys-C、HbA1c水平比较,差异有统计学意义(P<0.05);经LSD-t检验可知,研究B组IL-1β、HCY、Cys-C、HbA1c水平均高于对照组,而研究A组IL-1β、HCY、Cys-C、HbA1c水平均高于B组,差异有统计学意义(P<0.05);logistic回归分析可知,IL-1β、HCY、Cys-C、HbA1c水平与2型糖尿病周围神经病变有关(P<0.05);Spearman检验可知,IL-1β、HCY、Cys-C、HbA1c水平均与2型糖尿病周围神经病变呈正相关(P<0.05)。结论 IL-1β、HCY、Cys-C、HbA1c水平均与老年2型糖尿病周围神经病变呈正相关,临床工作中可通过IL-1β、HCY、Cys-C、HbA1c水平判定2型糖尿病周围神经病变患者。Objective To investigate the correlation of interleukin-1β（IL-1β）,homocysteine（HCY）,cystatin（Cys-C）and glycosylated hemoglobin（HbA1 c）levels and senile type 2 diabetic peripheral neuropathy.Methods 104 patients with type 2 diabetes mellitus received in the hospital from June 2014 to December 2016 were selected as study group,52 patients with peripheral neuropathy were served as study group A（n=52）and 52 patients with type 2 diabetes were served as study group B（n=52）,and 52 healthy persons who underwent health assessement were taken as the control group.The Cys-C level was measured by immunoturbidimetry,the levels of HCY and IL-1βwere measured by enzyme-linked immunosorbent assay.The HbA1 clevel was measured by high performance liquid chromatography,the IL-1β,HCY,Cys-C and HbA1 clevels were compared in the three groups,and the relationship between IL-1β,HCY,Cys-C and HbA1 clevels and senile type 2 diabetic peripheral neuropathy were analyzed.Results Single factor variance analysis showed that the levels of IL-1β,HCY,Cys-C and HbA1 cin the three groups were statistically significant（P〈0.05）;LSD-t test showed that the IL-1β,HCY,Cys-C and HbA1 clevels in the study group B were higher than those in control group,and IL-1β,HCY,Cys-C and HbA1 clevels in the study group A were higher than those in the study group B,and the difference was statistically significant（P〈0.05）;logisticis regression analysis showed that IL-1β,HCY,Cys-C,HbA1 clevels were associated with type 2 diabetic peripheral neuropathy（P〈0.05）;Spearman test showed that IL-1β,HCY,Cys-C,HbA1 clevels were positively correlated with type 2 diabetic peripheral neuropathy（P〈0.05）.Conclusion IL-1β,HCY,Cys-C and HbA1 clevels are positively correlated with senile type 2 diabetic peripheral neuropathy in the elderly,and the IL-1β,HCY,Cys-C and HbA1 clevels can be used to determine type 2 diabetic peripheral neuropathy in clinical work.

关 键 词：白细胞介素-1Β 同型半胱氨酸 胱抑素 糖化血红蛋白 2型糖尿病周围神经病变 

分 类 号：R587.2[医药卫生—内分泌] R446.1[医药卫生—内科学]