贝依在子宫腺肌病合并不孕患者行体外受精-胚胎移植治疗中的应用  

Application of Evan Bayh in the treatment of adenomyosis with infertility by IVF-ET

作　　者：李著艳 龚宝兰 马亚琳 LI Zhuyan;GONG Baolan;MA Yalin(Department of Gynaecology,the People′s Hospital Affiliated to Hubei MedicalCollege,Shiyan,Hubei 442000,China)

机构地区：[1]湖北医药学院附属人民医院妇科,湖北十堰442000

出　　处：《国际检验医学杂志》2018年第12期1451-1454,共4页International Journal of Laboratory Medicine

基　　金：国家自然科学基金资助项目(81272866)

摘　　要：目的探讨醋酸亮丙瑞林微球(贝依)在子宫腺肌病合并不孕患者行体外受精-胚胎移植(IVF-ET)治疗中的应用效果。方法选择2012年1月至2016年5月在该院生殖医学中心接受IVF-ET的子宫腺肌病合并不孕患者122例作为研究对象,根据随机数字表法将其分为试验组与对照组,各61例。试验组给予注射贝依治疗,对照组给予注射醋酸曲普瑞林治疗,然后均给予体外受精-胚胎移植治疗,调查与随访预后情况。结果试验组促性腺激素类药物(Gn)使用剂量少于对照组,且Gn使用时间也明显低于对照组,差异有统计学意义(P<0.05)。试验组人绒毛膜促性腺激素(HCG)注射日的促黄体生成素(LH)明显高于对照组,而雌二醇(E2)、孕酮(P)与子宫内膜厚度明显低于对照组,差异有统计学意义(P<0.05)。试验组的获卵数、可移植胚胎数低于对照组,周期取消率高于对照组,差异有统计学意义(P<0.05),但两组临床妊娠率比较,差异无统计学意义(P>0.05)。结论贝依在子宫腺肌病合并不孕患者行IVF-ET治疗中的应用能减少Gn使用剂量与使用时间,促进性激素分泌正常,提高患者的获卵数、可移植胚胎数,降低周期取消率,有很好的应用价值。Objective To investigate the effects of leuprolide acetate microspheres（Evan Bayh）in the treatment of adenomyosis with infertility by IVF-ET.Methods From January 2012 to May 2016,122 cases of adenomyosis combined with infertility were selected in the reproductive medicine center of the hospital as the research subjects,all the patients were randomly divided into experimental group and control group with 61 patients in each group according to the order of admission,the experimental group was received injection of Evan Bayh,the control group was given injection of triptorelin acetate treatment,and then all patients were given the in IVF-ET treatment,investigation and prognosis.Results The dosage of gonadotropins（Gn）in the experimental group was less than that in the control group,and the use time of Gn was lower than that of the control group,and the differences between the two groups were statistically significant（P〈0.05）.The luteinizing hormone（LH）in the experimental group was significantly higher than that in the control group at the human chorionic gonadotropin（HCG）injection time,while the estradiol（E2）,progesterone（P）and endometrium thickness were significantly lower than those of the control group（P〈0.05）.The number of retrieved eggs and the number of transplantable embryos in experimental group were lower than those in control group（P〈0.05）,the rate of cycle cancellation was higher than that of control group（P〈0.05）,and there was no significant difference in clinical pregnancy rate compared between the two groups（P〈0.05）.Conclusion The application of Evan Bayh in adenomyosis combined with infertility patients in the treatment of IVF-ET can reduce the dose of Gn and the use of time,promote normal hormone secretion,improve the patient′s oocyte number,the number of embryos,reduce the cycle cancellation rate,and has good application value.

关 键 词：贝依 子宫腺肌病 不孕 体外受精-胚胎移植 

分 类 号：R711.6[医药卫生—妇产科学] R711.71[医药卫生—临床医学]