2,6-二溴苯甲磺酰氯的合成  

The synthesis of 2,6-dibromophenylmethanesulfonyl chloride

作　　者：李飞 赵春深[1,2,3] LI Fei;ZHAO Chunshen( School of Pharmaceutical Sciences,Guizhou University,Guiyang 550025,China; School of Pharmaceutical Sciences,GuizhouEngineering Laboratory for Synthetic Drugs,Guizhou University,Guiyang 550025,China; School of Liquor and Food Engineering,Key Laboratory of Guizhou for Fermentation Engineering and Biopharmaceuticals,Guizhou University,Guiyang 550025,China)

机构地区：[1]贵州大学药学院,贵州贵阳550025 [2]贵州大学药学院贵州省药物合成工程实验室,贵州贵阳550025 [3]贵州大学酿酒与食品工程学院贵州省发酵工程与生物制药重点实验室,贵州贵阳550025

出　　处：《化学研究与应用》2018年第6期994-997,共4页Chemical Research and Application

基　　金：贵州省科技厅社发公关项目(黔科合SY字[2014]3054)资助;贵州省科技合作计划项目(黔科合LH字[2015]7680号和LH字[2016]7442号)资助

摘　　要：2,6-二溴苯甲磺酰氯是合成磺胺类药物活性分子的重要中间体,对2,6-二溴苯甲磺酰氯的合成工艺进行了研究。本文以间二溴苯为起始原料,经酰化、还原、氯代、取代和磺酰化反应合成了标题化合物,其结构经MS、~1H NMR、^(13)C NMR确证。该方法原料廉价易得,操作简便易控且收率较高,反应总收率为45%。2,6-Dibromobenzenesulfonyl chloride is an important intermediate for the synthesis of a variety of sulfa-drugs which exhibit pharmacological activities.The synthesis technoogy of 2,6-dibromobenzenesulfonyl chloride was studied in this paper.The target compound was synthesized by acylation,reduction,chlorination,substitution and sulfonylation reaction with m-dibromobenzene as the starting material.The structure was confirmed by MS,^1H NMR,^（13）C NMR.The raw materials were cheap and easy to get in this method.It was easy to operate and control the reaction and the yield was higher in each step,and the total yield was 45%.

关 键 词：2 6-二溴苯甲磺酰氯 磺胺类药物 合成 

分 类 号：O623.84[理学—有机化学]