血清胱抑素C和尿微量清蛋白检测早期肾功能损害的效果  

The Effect of Serum Cystatin C and Urinary Microalbumin Detection on Early Renal Impairment

作　　者：谢炜群 董建新[1] 戴冬琴 XIE Weiqun;DONG Jianxin;DAI Dongqin(Department of Internal Medicine,Affiliated Hospital of Medical College of Jiaying University,Meizhou Guangdong 514000,China)

机构地区：[1]梅州市嘉应学院医学院附属医院内科,广东梅州514000

出　　处：《中国卫生标准管理》2018年第11期43-45,共3页China Health Standard Management

摘　　要：目的研究血清胱抑素C(C's C)和尿微量清蛋白(Malibu)用于慢性肾小球肾炎患者早期肾功能损害诊断中的价值。方法回顾性分析2015年3月—2017年5月收治的80例慢性肾小球肾炎伴有早期肾功能损害患者的临床资料,设为观察组;选取同期体检的健康人80例为对照组;两组受检对象均接受尿微量清蛋白和血清胱抑素C检验。结果观察组患者的尿微量清蛋白、血清胱抑素C比对照组健康人高,P<0.01;观察组80例患者的尿微量清蛋白、血清胱抑素C阳性率分别为85.0%、80.0%,二者差异不具有统计学意义,P>0.05。结论Malibu、C's C在慢性肾小球肾炎患者早期肾功能损害诊断中具有重要价值,灵敏度高,二者均可以作为早期肾功能损害预测、诊断的重要指标。Objective To study the value of serum cystatin C（C＇s C） and urinary microalbumin（Malibu） detection in the diagnosis of early renal impairment in patients with chronic glomerulonephritis. Methods The clinical data of 80 patients with chronic glomerulonephritis and early renal impairment who were admitted to the hospital from March 2015 and May 2017 were retrospectively analyzed. The data were taken as the observation group; 80 healthy people who were selected for the same period physical examination were used as the control group. Both groups of subjects underwent C＇s C and Malibu tests. Results Malibu and C＇s C in the observation group were higher than those in the control group（P 〈0.01）. The Malibu and C＇s C positive rates in the observation group were 85.0% and 80.0%, respectively. There was no significant difference between the two groups（P 〉0.05）. Conclusion Malibu and C＇s C have important value in the diagnosis of early renal dysfunction in patients with chronic glomerulonephritis and have high sensitivity. Both of them can serve as important indicators for the prediction and diagnosis of early renal impairment.

关 键 词：慢性肾小球肾炎 早期肾功能损害 肾小球滤过 血清胱抑素 尿微量清蛋白 诊断 

分 类 号：R692[医药卫生—泌尿科学]