血清胆碱酯酶测定在脓毒症患者中的应用价值  

Value of Serum Cholinesterase Determination in Patients With Sepsis

作　　者：耿英杰[1] GENG Yingjie(Department of Critical Care Medicine,Beijing Shijingshan Hospital,Beijing 100043,China)

机构地区：[1]北京市石景山医院重症医学科,北京100043

出　　处：《中国卫生标准管理》2018年第11期57-59,共3页China Health Standard Management

摘　　要：目的探讨血清胆碱酯酶水平与脓毒症患者病情严重程度及预后的关系。方法分析脓毒症患者50例,按照入院24小时内APACHEⅡ评分不同分为2组,其中≤20分为A组,≥21分为B组,测定入院24小时内血清胆碱酯酶水平,分析其与APACHEⅡ评分的关系。结果全组患者血清胆碱酯酶水平与APACHEⅡ评分呈负相关(r=-0.444,P<0.05);B组血清胆碱酯酶水平低于A组(P<0.05),死亡组血清胆碱酯酶水平低于存活组(P<0.05)。结论血清胆碱酯酶测定对于早期评估脓毒症患者病情严重程度和预后具有一定价值。Objective To exlpore the relationship between serum levels of cholinesterase and severity and prognosis of sepsis. Methods 50 patients defined as sepsis were assigned into 2 groups according to the APACHE-II score within 24 hours of admission. The patients whose APACHE-II score ≤ 20 were assigned into Group A. The patients whose APACHE-II score 〉20 were assigned into Group B. The contents of serum cholinesterase in group A and group B were determined within 24 h of hospital to analyze its relationship with APACHE-II score. Results The serum cholinesterase level was negatively correlated with APACHEII score（r =-0.444, P =0.05）. The serum cholinesterase level in group B was significantly lower than that in group A（P〈0.05）, and the serum cholinesterase level in death group was significantly lower than that in survival group（P〈0.05）. Conclusion The determination of serum cholinesterase is valuable for early assessment of the severity and prognosis of sepsis.

关 键 词：脓毒症 胆碱酯酶 APACHE Ⅱ评分 严重程度 预后 早期 

分 类 号：R331[医药卫生—人体生理学]