MMP-3/TIMP-1、Th17/Treg在类风湿关节炎中的作用及其临床意义  

The role and clinical significance of MMP-3/TIMP-1,Th17/Treg in rheumatoid arthritis

作　　者：崔静 王晓霞[1] 王洪[1] 郝振叶 郭莹莹 陈慧芳 何佳莉 CUI Jing;WANG Xiaoxia;WANG Hong;HAO Zhenye;GUO Yingying;CHEN Huifang;HE Jiali(Department of Rheumatology,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第二医院风湿免疫科,山西太原030001

出　　处：《中国现代医生》2018年第13期160-163,168,共5页China Modern Doctor

基　　金：山西省科技攻关项目(20150313008-4)

摘　　要：多种研究表明,基质金属蛋白酶-3(matrix metalloproteinase,MMP-3)的高表达在类风湿关节炎(rheumatoid arthritis,RA)滑膜、软骨和软骨下骨的细胞外间质的降解中充当重要角色。金属蛋白酶组织抑制剂-1(tissue inhibitors of metalloproteinase1,TIMP-1)与MMP-3特异结合,抑制MMP-3的活性,MMP-3/TIMP-1平衡对RA的临床结局有着重要作用。新的研究发现,抑制Th17细胞分化,维持Treg细胞(regulatory T cell)活性,调节Th17/Treg平衡,可为治疗RA提供新的作用靶点。进一步研究发现,RA早期患者外周血MMP-3与白介素17(Interleukin17,IL-17)表达明显升高,两者呈正相关,Treg的下降可影响MMP-3/TIMP-1的平衡。本文将对MMP-3/TIMP-1和Th17/Treg在RA中的作用机制及其临床意义作一综述。Various studies have shown that the high expression of matrix metalloproteinase-3（MMP-3） is involved and play an important role in the degradation of the extracellular matrix of synovium, cartilage and subchondral bone of rheumatoid arthritis（RA）. Tissue inhibitor of metalloproteinase 1（TIMP-1） binds specifically to MMP-3 and inhibits the activity of MMP-3. The balance of MMP-3/TIMP-1 plays an important role in the clinical outcome of RA. New research found that inhibiting Th17 cell differentiation,maintaining Treg（regulatory T cell） activity and regulating Th17/Treg balance may provide novel targets for the treatment of RA. Further study found that the expression of MMP-3 and Interleukin 17（IL-17） in the peripheral blood of RA patients was significantly increased, the two were positively correlated, and the decrease of Treg could affect the balance of MMP-3/TIMP-1. This article will review the mechanism of MMP-3/TIMP-1 and Th17/Treg in RA and its clinical significance.

关 键 词：类风湿关节炎 基质金属蛋白酶3 金属蛋白酶组织抑制剂-1 Th17细胞 TREG细胞 肿瘤坏死因子α拮抗剂 

分 类 号：R593.2[医药卫生—内科学]