消岩汤联合针灸疗法对化疗相关性疲乏影响的临床研究  

Clinical study of Xiaoyan decoction combined with acupuncture and moxibustion therapy on fatigue related to chemotherapy

作　　者：张丽丽[1] 李文涛[1] 李海鹏[2] 贾英杰[1] ZHANG Lili1, LI Wentao1, LI Haipeng2, JIA Yingjie1(1. The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China; 2.Tianjin University ofTraditional Chinese Medicine, Tianjin 300193, China)

机构地区：[1]天津中医药大学第一附属医院,天津300193 [2]天津中医药大学,天津300193

出　　处：《天津中医药》2018年第7期498-502,共5页Tianjin Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81273937)

摘　　要：[目的]观察消岩汤联合针灸疗法对化疗相关性疲乏的影响。[方法]将80例患者按随机数字表法分为治疗组(40例)和对照组(40例)。两组患者根据病情需要均采用既定化疗方案化疗,治疗组从化疗第1天开始口服消岩汤(每日1剂,水煎服,300 mL,早晚分2次服用,连服3周)同时配合针灸治疗(每日1次,共3周)。对照组未给予其他干预措施。分别在化疗前、化疗第7天和化疗第21天采用癌性疲乏量表(CFS)、中医证候疗效评价及癌症治疗功能评估疲乏量表(FACT-F)比较两组患者在化疗前、化疗第7天、第21天疲乏、中医症状积分、生活质量的变化,并进行中医证候疗效比较。[结果]与本组化疗前比较,治疗组化疗第7天CFS在情感维度、躯体维度及总分较化疗前增加(P<0.05);对照组化疗第7天、第21天CFS各维度及总分均较化疗前增加(P<0.05)。与本组化疗第7天比较,化疗第21天治疗组CFS各维度及总分均下降(P<0.05);对照组情感维度及总分下降(P<0.05)。两组同期比较治疗组CFS各维度及总分均明显低于对照组(P<0.01);中医症状积分治疗组总有效率为90.0%,明显优于对照组20.0%(P<0.01);中医症状评分:与本组化疗前比较,治疗组化疗第7天患者的症状积分升高(P<0.05),第21天症状积分明显降低(P<0.01),对照组化疗第7天、第21天症状积分均升高(P<0.01);与本组化疗第7天比较,两组化疗第21天治疗症状积分减低(P<0.01),两组同期(除治疗前)比较治疗组症状积分均低于对照组(P<0.01);生活质量评分:与本组化疗前比较,治疗组化疗第7天情感状况及功能状况评分下降(P<0.05),第21天身体状况、情感状况、附加状况评分升高(P<0.05);对照组化疗第7天各项指标评分均下降(P<0.05),化疗第21天身体状况、功能状况及附加状况评分降低(P<0.05);与本组化疗第7天比较,治疗组与对照组各项指标评分均升高(P<0.05);两组同期(除治疗前)对比治疗组�[Objective] To observe the effect of Xiaoyan decoction combined with acupuncture on the fatigue related to chemotherapy.[Methods] The 80 patients were randomly divided into treatment group （40 cases） and control group （40 cases）. The two groups weretreated with chemotherapy regimen according to the needs of the disease. The treatment group started oral Xiaoyan Decoction （1 dosesdaily, water decoction, 300 mL, 2 times and 3 weeks） from the first day of chemotherapy and combined with acupuncture and moxibustionfor 3 weeks （1 times a day for a total of 3 weeks）. The control group did not give other intervention measures. Before chemotherapy,seventh days of chemotherapy and twenty-first days of chemotherapy, the cancer fatigue scale （cancer fatigue scale, CFS）, TCM SyndromeEvaluation and cancer treatment function evaluation Fatigue Scale （FACT-F） were used to compare the changes of fatigue, TCM syndromescore and quality of life in two groups before chemotherapy, seventh days of chemotherapy, twenty-first days of chemotherapy, and thechange of quality of life. The curative effect of medical syndrome was compared. [Results] Compared with this group beforechemotherapy, the seventh days of CFS in the treatment group increased （P〈0.05） in the emotional dimension, body dimension and totalscore than before chemotherapy （P〈0.05）, and the CFS dimensions and total scores of the control group increased （P〈0.05） beforechemotherapy, and the total score of CFS was higher than that before chemotherapy （P 〈0.05）. Compared with the seventh days ofchemotherapy in this group, all the dimensions and total scores of CFS in the twenty-first day chemotherapy group decreased （P〈0.05）,and the emotional dimension and total score of the control group decreased （P〈0.05）. The dimensions and total scores of CFS in the twogroups were significantly lower than those in the control group （P〈0.01）, and the total effective rate of TCM syndrome integral treatmentgroup was 90% significantl

关 键 词：化疗相关性疲乏 针灸疗法 癌性疲乏量表 生活质量 

分 类 号：R273[医药卫生—中西医结合]