ESI-HRMS法在梓醇丙酰化产物合成过程分析中的应用  

Application of ESI-HRMS method in analysis of the synthesis process of catalpol propionylated products

作　　者：王国庆[1] 褚铭林 李振兴[1] 于文浩[1] 董春红 王强[3] WANG Guoqing;CHU Minglin;LI Zhenxing;YU Wenhao;DONG Chunhong;WANG Qiang(College of Materials and Chemical Engineering,Zhengzhou University of Light Industry,Zhengzhou 450001,China;College of Pharmacy,He＇nan University of Chinese Medicine,Zhengzhou 450046,China;He＇nan Analysis and Testing Centre,Zhengzhou 450002,China)

机构地区：[1]郑州轻工业学院材料与化学工程学院,河南郑州450001 [2]河南中医药大学药学院,河南郑州450046 [3]河南省分析测试中心,河南郑州450002

出　　处：《轻工学报》2018年第3期1-7,共7页Journal of Light Industry

基　　金：国家自然科学基金项目(81373462);国家自然科学基金国际合作与交流基金中泰合作项目(8151101082)

摘　　要：采用电喷雾离子化-高分辨质谱(ESI-HRMS)法对梓醇丙酰化产物进行定性确认,利用峰面积归一化法对各产物进行半定量分析,建立了梓醇丙酰化过程分析方法.结果表明:ESI-HRMS法可以快速定性丙酰化产物的种类,而峰面积归一法可以计算得到各梓醇丙酰化产物的相对含量,由此可以根据需要,通过控制反应条件,合成有特定结构的主产物或混合产物.ESI-HRMS法在梓醇丙酰化过程分析中的应用,为梓醇丙酰化产物合成过程分析提供了新途径.Using electrospray ionization-high resolution mass spectrometry（ ESI-HRMS） method to confirm the catalpol propionylated products,and using peak area normalizing method to complete the semi quantitative,the analysis method on the synthesize process of catalpol propionylated products was established. The results showed that the ESI-HRMS method could quickly determine the type of propionylated products; the peak area normalization method could calculate the relative content of each catalpol propionylated products,which could be controlled to synthesize the main or mixed products with the specific structure by controlling the reaction conditions according to the need. The application of ESI-HRMS method in the reaction process of catalpol propanolation could provide a new approach for the analysis of the synthesis process of catalpol propanylated products.

关 键 词：梓醇 丙酰化 电喷雾离子化-高分辨质谱 过程分析 

分 类 号：O657.63[理学—分析化学] TS218.2[理学—化学]