基于脂质体的纳米基因载体的研究进展  

Research Progress of Nano-Gene Carriers Based on Liposomes

作　　者：韩旭 丁冠宇 董青[1] 李云辉[1] 杨秀云[1] 李丹[2] 杜衍[2] 汪尔康[2] HAN Xu;DING Guanyu;DONG Qing;YANG Xiuyun;LI Dan;DU Yan;WANG Erkang(Key Laboratory of Preparation and Applications of EnvironmentalFriendly Materials,Jilin Normal University,Changchun 130103,China;State Key Laboratory of Rare Earth Resource Utilization,Changchun Institute of Applied Chemistry,CAS,Changchun 130022,China;Department of Chemistry,University of Science and Technology of China,Hefei 230026,China;Jiangxi Jiangwu Haoyun High-tech Co.,Ltd,Nanchang 330096,China)

机构地区：[1]长春理工大学化学与环境工程学院,长春130022 [2]中国科学院长春应用化学研究所,电分析化学国家重点实验室,长春130022

出　　处：《应用化学》2018年第7期735-744,共10页Chinese Journal of Applied Chemistry

摘　　要：基因治疗是指将外源基因导入目标细胞,用以修正因基因缺陷和异常导致的疾病,达到治疗疾病的目的。外源基因在细胞中高效、持续地表达是基因治疗成功的关键,这与载体的选择息息相关。随着科技的发展,脂质体纳米复合物作为基因载体受到人们广泛关注,其具有功能多样、易于修饰、生物相容性好、转染效率高等优点。本文介绍了脂质体的结构特点,并对磁性纳米、金纳米、量子点、壳聚糖、上转换纳米与脂质体的复合物作为基因载体进行综述和展望。Gene therapy is a method for curing diseases caused by genetic defects and anomalies through introducing normal foreign genes into targeted cells. Efficient and sustained expression of foreign genes in cells is the decisive factor in gene therapy,which is significantly relied on the vectors used in the treatment. With the development of science and technology,the research of liposome/nanocomposites as gene carriers has widely attracted people＇ s attention, due to the following advantages： versatile functions, easy surface modification,good biocompatibility,high transfection efficiency. Herein,the structure of liposome bilayer was introduced and the complexes of magnetic nanoparticles, gold nanoparticles, quantum dots, chitosan,upconversion nanoparticles with liposomes as gene carriers have been reviewed and prospected.

关 键 词：脂质体 基因载体 纳米材料 

分 类 号：O641.3[理学—物理化学]