抗氧化聚砜血液透析膜的构建与性能研究  

Study on the construction and performance of antioxidant polysulfone membrane for hemodialysis

作　　者：王丹丹[1] 杨宁[1] 贾雪梦 袁光昊 陈莉[1] 赵义平[1] WANG Dandan , YANG Ning , JIA Xuemeng , YUAN Guanghao , CHEN Li , ZHAO Yiping(State Key Laboratory of Separation Membranes and Membrane Processes, School of Materials Science and Engineering, Tianjin Polytechnic University, Tianjin 300387, China)

机构地区：[1]省部共建分离膜与膜过程国家重点实验室天津工业大学材料科学与工程学院,天津300387

出　　处：《膜科学与技术》2018年第2期22-28,44,共8页Membrane Science and Technology

基　　金：国家自然科学基金(31200719&21374078);天津市科技计划项目(15PTSYJC00250;15JCYBJC17900;17YFZCSF01230);教育部创新团队项目(IRT13084)

摘　　要：为了抑制血液透析过程中氧化应激现象,以聚砜(PSf)为膜材料,水飞蓟宾-卵磷脂(SPC)为改性剂,采用浸没沉淀相转化法制备抗氧化的SPC/PSf血液透析膜.随着SPC在铸膜液中含量的提高,SPC/PSf杂化膜纯水通量增大到(187.9±6.9)L/(m^2·h)、亲水性提高,SPC/PSf膜对1,1-二苯基-2-三硝基苯肼(DPPH)和2′-联氨-双-3-乙基苯并噻唑啉-6-磺酸(ABTS)最高清除率分别可达到88.3%±1.3%和99.4%±0.3%,抗氧化性提高.SPC/PSf膜相比于纯PSf膜不仅血小板黏附量减少,细胞增殖能力增强,而且具有较强的抑制超氧化物歧化酶(SOD)产生的能力.结果表明,该SPC/PSf血液透析膜可望应用于血液透析领域,缓解病人的氧化应激状态.The objective of this study is to improve the antioxidant properties of polysulfone （PSf）hemodialysis membranes through hybrid silybin-phosphatidylcholine complex （SPC）.The SPC/PSf hemodialysis membrane with antioxidant activity was made using PSf as membrane material by liquid-liquid phase separation method in the presence of SPC as modifier to suppress hemodialysis induced oxidative stress.For the SPC/PSf hybrid membrane,the pure water flux was increased to （187.9and a new type of SPC/PSf hemodialysis membrane was expected to be applied in the field of hemodialysis and alleviate the oxidative stress status of the patients.

关 键 词：水飞蓟宾-卵磷脂 聚砜 血液透析膜 抗氧化 生物相容性 

分 类 号：TQ316[化学工程—高聚物工业]