慢性鼻-鼻窦炎伴鼻息肉患者鼻内镜术后复发的危险因素分析  

Analysis of risk factors of recurrence for patient with chronic rhinosinusitis with nasal polyps after endoscopic sinus surgery

作　　者：冯娟[1] 王燕[1] 阳玉萍[1] 周伟[1] 张波[1] 阿依恒.曲库尔汗[1] 张华[1] FENG Juan;WANG Yan;YANG Yuping;ZHOU Wei;ZHANG Bo;Ayiheng Qukuerhan;ZHANG Hua(Department of Otorhinolaryngology,the First Affiliated Hospital,Xinjiang Medical University,Urumqi 830054,China)

机构地区：[1]新疆医科大学第一附属医院耳鼻咽喉科,乌鲁木齐830054

出　　处：《新疆医科大学学报》2018年第6期670-673,共4页Journal of Xinjiang Medical University

基　　金：国家自然科学基金(81570896)

摘　　要：目的探讨慢性鼻-鼻窦炎伴鼻息肉患者鼻内镜术后息肉复发的相关危险因素。方法回顾性分析2010年1月-2016年5月在新疆医科大学第一附属医院耳鼻喉科住院的慢性鼻-鼻窦炎伴鼻息肉患者459例,根据病情将其分为初发组和复发组,其中初发组344例,复发组115例。采集患者的年龄、性别、吸烟史、饮酒史、病程、是否伴有变应性鼻炎、哮喘、血中嗜酸性粒细胞百分比、鼻息肉病理组织类型共9个指标进行统计学分析,筛选出有统计学意义的指标,将入选指标进行多因素Logistic回归分析,得出影响慢性鼻-鼻窦炎伴鼻息肉患者术后复发的危险因素。结果 2组患者病程、哮喘、变应性鼻炎、嗜酸性粒细胞浸润型鼻息肉差异具有统计学意义(P<0.05),采用多因素Logistic回归分析显示,哮喘、嗜酸性粒细胞浸润型鼻息肉的是慢性鼻-鼻窦炎伴鼻息肉鼻内镜术后息肉复发的危险因素(P<0.05)。结论伴有哮喘及嗜酸性粒细胞浸润型鼻息肉是慢性鼻-鼻窦炎伴鼻息肉鼻内镜术后复发的危险因素。Objective To investigate the risk factors of the postoperative recurrence of chronic rhinosinusitis with nasal polyps after endoscopic sinus surgery.Methods 459 patients with chronic rhinosinusitis with nasal polyps were treated surgically in the department of otolaryngology of the first affiliated hospital of Xinjiang medical university from January 2010 to May 2016 was retrospectively analyzed,and these patients were divided into primary group（344 cases）and recurrence group（115 cases）.Nine factors including patients＇ age,gender,smoking,alcoholic drinking,disease duration,combination with allergic rhinitis,combination with asthma,the eosinophil percentage of peripheral blood and histopathological classification of nasal polyp were statistically analyzed and significant variables were filtered out.Risk factors of postoperative recurrence of nasal polyps were found by multifactor logistic regression analysis.Results There was significant difference of disease duration,combination with asthma,combination with allergic rhinitis and histopathologically classification of nasal polyp tissue between two groups（P〈0.05）.These four factors were analyzed by multifactor regression analysis,we found combination with asthma and histopathologically eosinophilic nasal polyps were risk factors,which affected the recurrence of chronic rhinosinusitis with nasal polyps after operation（P〈0.05）.Conclusion Combination with asthma and eosinophilic nasal polyps were risk factor which were associated with postoperative recurrence of chronic rhinosinusitis with nasal polyps.

关 键 词：慢性鼻-鼻窦炎伴鼻息肉 复发 危险因素 

分 类 号：R76[医药卫生—耳鼻咽喉科]