中风膏对颈动脉粥样硬化患者血清炎性细胞因子及颈动脉内膜中层厚度的影响  

Effects of Stroke Ointment on Inflammatory Cytokines and Carotid intima-media Thickness of the Patients with Carotid Atherosclerosis

作　　者：王晓萍[1] 杜改焕[1] 曹骅[1] WANG Xiaoping;DU Gaihuan;CAO Hua(Gansu Provincial Hospital of Traditional Chinaese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃省中医院,甘肃兰州730050

出　　处：《西部中医药》2018年第6期6-9,共4页Western Journal of Traditional Chinese Medicine

基　　金：甘肃省中医药管理局项目(编号GZK-2012-2)

摘　　要：目的:观察中风膏对颈动脉粥样硬化(CAS)患者血清肿瘤坏死因子α(TNF-α)、神经内血管内皮细胞黏附分子1(VCAM-1)和单核细胞趋化蛋白(MCP-1)表达水平及颈动脉内膜中层厚度(IMT)的影响。方法:将150例CAS患者随机分为中风膏组(中药组)、阿托伐他汀钙组(西药组)与中风膏联合阿托伐他汀钙组(联合组),每组50例,各组均给予常规基础治疗,3个月为1个疗程,连续观察2个疗程。观察各组干预前后血清TNF-α、MCP-1、VCAM-1及IMT的变化情况。结果:中药组、西药组、联合组TNF-α、MCP-1、VCAM-1表达水平明显下降(P<0.05),西药组与中药组比较,差异有统计学意义(P<0.05),联合组与西药组比较差异有统计学意义(P<0.05)。西药组、联合组IMT均显著改善差异有统计学意义(P<0.05);中药组能够下降IMT,但差异无统计学差异(P>0.05);联合组与西药组比较差异有统计学意义(P<0.05)。结论:中风膏通过抑制CAS患者血清炎性细胞因子的表达与释放,发挥保护血管内皮的作用。中风膏联合阿托伐他汀钙干预能够延缓颈动脉IMT增厚,提高临床治疗效果。Objective：To observe the effects of stroke ointment on carotid intima-media thickness（IMT） and the expressions of MCP-1, VCAM-1 and TNF-α in the serum of the patients with carotid atherosclerosis（CAS）.Methods：All 150 CAS patients were randomized into stroke ointment group（herb group）, atorvastatin calcium group（western medicine group） and the combination group, 50 cases each group, different groups accepted conventional therapies, three months were one course, for two courses consecutively. The changes of MCP-1,VCAM-1 and TNF-α as well as IMT in different groups were observed before and after the intervention. Results：The expressions of TNF-α, MCP-1 and VCAM-1 in the herb group, western medicine group and the combination group descended notably（P〈0.05）, western medicine group was more significant than the herb group, and the difference had statistical meaning（P〈0.05）, the combination group was more significant than western medicine group, and the difference had statistical meaning（P〈0.05）. IMT improved in the western medicine group and the combination group significantly（P〈0.05）, IMT fell in the herb group, while there was no statistical difference（P〈0.05）; the combination group was more notable than western medicine group, and the difference had statistical meaning（P〈0.05）. Conclusion：Stroke ointment could play the roles of protecting blood vessel endothelium by inhibiting the expression and the release of inflammatory cytokines in the serum of CAS patients. When it is combined with atorvastatin calcium in the intervention, it could delay thickening of carotid IMT and raise therapeutic effects.

关 键 词：颈动脉粥样硬化 中风膏 阿托伐他汀钙 炎性细胞因子 

分 类 号：R255.2[医药卫生—中医内科学]