功能化聚富马酸对苯二甲酸二环氧丁烷马来酸酯多孔支架的制备及性能研究  

Preparation and properties of functional polyester porous scaffold

作　　者：梁嘉辉 吕姿颖 谢阳芬 游正伟[1] Liang Jiahui;Lv Ziying;Xie Yangfen;You Zhengwei(State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,College of Materials Science and Engineering,Donghua University,Shanghai 201620,China)

机构地区：[1]纤维材料改性国家重点实验室东华大学材料科学与工程学院,上海201620

出　　处：《合成技术及应用》2018年第2期14-17,共4页Synthetic Technology & Application

基　　金：国家自然科学基金项目21574019;81320108010;国家高技术研究发展计划863计划项目2015AA020311

摘　　要：具有良好力学性能以及生物活性等特性的三维多孔支架材料在组织工程及组织器官修复领域扮演着日益重要的角色。本文基于新型功能聚酯聚富马酸对苯二甲酸二环氧丁烷马来酸酯(PTFB-M),通过盐析法制备了多孔支架,通过扫描电镜(SEM)图像研究了其微观三维结构。利用差示扫描量热分析(DSC)和热重分析(TGA)研究了其热力学性能。同时对多孔支架进行了循环压缩测试。最后,对PTFB-M多孔支架化学键连接生长因子,并进行了生长因子缓释实验。Three dimensional scaffolds have played an important role on tissue engineering,which is a research field focusing on repairing and reconstruction damaged tissues. Here,we prepared poly（ fumaroylterephthaloylbioxirane） maleate porous scaffold with 3 D porous structure by salt particulate leaching technique. The microscopic 3 D-structure of PTFB-M porous scaffold was investigated by SEM. The thermal properties were investigated by DSC and TGA. The compression test was also performed. Finally,we covalently bonded the growth factor to scaffolds and investigated its release profile.

关 键 词：功能化聚酯 多孔支架 组织工程 生长因子 缓释 

分 类 号：TQ322.2[化学工程—合成树脂塑料工业]