微波热声实时成像系统及应用  

Microwave Thermoacoustic Real-time Imaging System and Its Application

作　　者：崔永胜 计钟 CUI Yongsheng;JI Zhong(MOE Key Laboratory-of Laser Life Science ＆ Institute of Laser Life Science,College of Biophotonics,South China Normal University,Guangzhou 510631,Guangdong,China)

机构地区：[1]华南师范大学,生物光子学研究院激光生命科学研究院,暨激光生命科学教育部重点实验室,广东广州510631

出　　处：《激光生物学报》2018年第1期81-86,共6页Acta Laser Biology Sinica

基　　金：国家自然科学基金(61627827,81630046,61331001,91539127);中国国家高新技术研究与发展项目(2015AA020901);广东省科技项目(2015B020233016,2014B020215003,2017A020215135,2014A020215031);华南师范大学青年教师科学研究培育基金(16KJ05);中国博士后科学基金(2017M610533);广东省普通高校青年创新人才项目(2016KQNCX034)

摘　　要：本文建立了一套微波热声实时成像系统,该系统由脉冲微波发生器,多元环形探测器,多通道数据采集装置和数据重建装置共同组成。在实验中,利用填充盐水的两个塑料管验证其实时成像的性能,结果表明,该系统能够实现每秒16.7帧的成像速度。随后,对活体小鼠的正常区域和肿瘤区域分别进行热声成像,得到肿瘤和正常区域的对比度为1.7∶1,证明了该系统在肿瘤检测中有较高的对比度。最后,利用该系统监控细管趋近离体肿瘤的过程。因此该系统有望应用于实时监测。综上所述,该热声成像系统具有无损,成像速度快和大视场的良好性能,有望在生物医学中得到广泛的应用,尤其在肿瘤筛查和实时监控方面发挥作用。A set of real-time microwave thermoacoustic imaging system was established. The system was composed of a pulsed microwave generator,a multi-element ring-shaped detector,a multi-channel data acquisition and a data reconstruction device. From experiments,the performance of the two plastic tubes filled with physiological saline was verified,and the results showed that the imaging speed was 16. 7 frames per second. Subsequently,the normal and tumor area of the living mice were imaged,respectively,and the contrast between the tumor and normal area was 1. 7 ∶ 1,which proved that the system had a high contrast in tumor detection. Finally,a dynamic process monitoring experiment was implemented. In summary,the established system has the advantage of non-invasive,fast imaging speed and large field of view,and is expected to be widely used in biomedicine,especially real-time tumor screening and monitoring.

关 键 词：脉冲微波 热声成像 实时成像 

分 类 号：R318.51[医药卫生—生物医学工程]