Wnt3a与Wnt5a信号途径转换对造血干细胞衰老的影响  

Effects of Wnt3a and Wnt5a signaling pathway switching on hematopoietic stem cells senescence

作　　者：李双 孙倩倩 余丽梅[1,2] 赵春华 LI Shuang;SUN Qian-qian;YU Li-mei;ZHAO Chun-hua(Key Laboratory of Cell Engineeling in Guizhou Province,the Affiliated Hospital of Zunyi Medical College,Zunyi 563003;the Team of Scientific and Technological Innovation Talents on the Basic and Clinical Research of Amniotic Membrane and Bone Marrow Stem Cells in Guizhou Province,Zunyi 563003;Genrer of Excellence Key Labolatory in Beijing,Institute of Basic Medical Sciences CAMS;School of Basic Medicine PUMC,Beijing 10000)

机构地区：[1]遵义医学院附属医院贵州省细胞工程重点实验室,贵州遵义563003 [2]贵州省羊膜与骨髓干细胞基础与临床研究科技创新人才团队,贵州遵义563003 [3]中国医学科学院基础医学研究所北京协和医学院基础学院中国医学科学院组织工程研究中心干细胞新药研发及临床转化研究北京市重点实验室,北京100005

出　　处：《基础医学与临床》2018年第5期703-707,共5页Basic and Clinical Medicine

基　　金：国家自然科学基金(81260507);贵州省生物治疗人才基地([2013]15);遵义市人才项目(15851)

摘　　要：造血干细胞(HSCs)衰老是机体造血免疫功能衰老的重要原因,在衰老相关疾病的发生中起着关键作用。一定条件下,经典Wnt3a/β-catenin的激活明显有利于保持HSCs的极性与年轻态、自我更新与增殖、分化能力;非经典Wnt5a信号通路的激活则可通过进一步激活细胞内Cdc42蛋白活化等,促发HSCs衰老,并间接抑制Wnt3a/β-catenin通路。对Wnt3a向Wnt5a信号通路转换及其干预的研究不但阐释了HSCs衰老发生的机制,更明确了如何延缓衰老,提供了解决衰老相关疾病及保持年轻态的新策略。Hematopoietic stem cells（ HSCs） senescence is an important reason of hematopoietical and immunological function senescence. It also is play a key role during aging-related diseases development. Under certain conditions,the activation of classical Wnt3 a/β-catenin is in favour of maintains polarity and young states of HSCs,selfrenewing,proliferation and differentiation potency. Switching to the non-classical Wnt5 a pathway,further activation of Cdc42 protein and others can promote HSCs ageing,and indirectly inhibits Wnt3 a/beta-catenin pathway. The intervention of two Wnt signaling pathways switching and mechanism,not only can illustrate the mechanism of HSCs aging,but also clear how to slow down ageing. This could provide a new strategy on the solution of age-related diseases and keeping a young state.

关 键 词：造血干细胞 衰老 WNT3A WNT5A 

分 类 号：R551[医药卫生—血液循环系统疾病]