海藻酸-壳聚糖微球的制备及其在生物医药领域的应用  

Preparation and biomedical applications of alginate-chitosan microspheres

作　　者：金鑫[1] 杨军星[1] 王英男 刘志辉[1] 王博蔚[3] Jin Xin;Yang Junxing;Wang Yingnan;Liu Zhihui;Wang Boweil(Dept.of Prosthodontics,Hospital of Stomatology,Jilin University,Changchun 130021,China;College of Chemistry,Jilin University,Changchun 130021,China;Dept.of Obstetrics and Gynecology,The Second Hospital of Jilin University,Changchun 130041,China)

机构地区：[1]吉林大学口腔医院修复科,长春130021 [2]吉林大学化学学院,长春130021 [3]吉林大学第二医院妇产科,长春130041

出　　处：《国际口腔医学杂志》2018年第4期414-419,共6页International Journal of Stomatology

基　　金：吉林省医药产业推进计划(20140311088YY);长春市重大科技攻关计划(2014054);吉林省科技攻关计划(20150204004YY);长春市“双十工程”计划(16SS12)~~

摘　　要：壳聚糖是唯一的天然碱性氨基多糖,海藻酸是一种天然阴离子多聚糖,这两种物质都具有良好的生物相容性,无细胞毒性,具有生物可降解性,是制备微球的良好材料。本文综合阐述了近年来国内外联合利用壳聚糖和海藻酸两种天然高分子物质制备微球的主要方法(包括离子交联法和乳化法),以及海藻酸-壳聚糖微球作为药物载体在生物医药领域的应用。Chitosan is the only natural alkaline amino polysaccharide, and alginate is a kind of natural anionic polysac- charide. These polysaccharides are good materials for microsphere preparation because of their good biocompatibility, nontoxicity and biodegradability. This paper reviews the main methods （ion crosslinking and emulsification） of microsphere preparation by using the combination of chitosan and alginate and its application as a drug carrier in biomedicine

关 键 词：壳聚糖 海藻酸 载药 控释 微球 

分 类 号：R318.08[医药卫生—生物医学工程]