利拉鲁肽对新诊断2型糖尿病合并肥胖/超重男性病人的血睾酮水平的影响  

Effect of liraglutide on the plasma testosterone level in T2DM male patiens complicated with obesity/overweight

作　　者：赵琳[1] 刘洋[1] 申晶[1] ZHAO Lin;LIU Yang;SHEN Jing(Department of Endocrinololy,The 309th PLA Hospital,Beijing 100091,China)

机构地区：[1]解放军第309医院内分泌科,北京100091

出　　处：《蚌埠医学院学报》2018年第4期501-502,506,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨皮下注射利拉鲁肽注射液治疗新诊断2型糖尿病(T2DM)合并肥胖/超重男性病人对血浆睾酮水平的影响。方法:入组新诊断肥胖/超重T2DM男性病人40例,随机分为在原治疗方案的基础上加用利拉鲁肽20例(观察组)和不加用利拉鲁肽20例(对照组),治疗6个月,观察利拉鲁肽注射液的临床疗效和对血浆睾酮的水平变化的影响。结果:治疗前2组空腹血糖(FPG)、糖化血红蛋白(Hb A1c)、胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)差异均无统计学意义(P>0.05)。治疗后,对照组FPG和Hb A1c较治疗前明显改善(P<0.01),观察组各项指标均较治疗前明显改善(P<0.01);且与对照组比较,观察组FPG和Hb A1c均降低(P<0.05和P<0.01),HOMA-β明显升高(P<0.01)。治疗后观察组睾酮水平明显高于治疗前(P<0.01),而对照组治疗前后睾酮水平差异无统计学意义(P>0.05);治疗前后,2组睾丸酮水平间差异均无统计学意义(P>0.05)。结论:利拉鲁肽能有效降低新诊断T2DM合并肥胖/超重病人血糖,改善胰岛β细胞功能,可提高血浆睾酮水平。Objective： To investigate the effects of liraglutide on the plasma testosterone level in type 2 diabetes mellitus（T2DM） male patients complicated with obesity/overweight.Methods： A total of 40 obese or overweight T2DM patients were randomly divided into the control group and observation group（20 cases each group）.The control group and observation group were treated with routine method and liraglutide combined with routine method,respectively.After 6 months of treatment,the clinical effiency of liraglutide,and effect of liraglutide on the plasma testosterone level were observed.Results： Before treatment,the differences of the levels of FPG,HbA1c,HOMA-IR and HOMA-β between two groups were not statistically significant（ P 〉0.05）.After treatment,the levels of FPG and HbA1c in control group,and all indexes in observation group were significantly improved compared with before treatment（ P 〈 0.01 ）.Compared with the control group,the levels of FPG and HbA1c,and level of HOMA-β in observation group significantly decreased and increased after treatment,respectively（ P 〈0.05 to P 〈0.01）.The plasma level of testosterone in observation group after treatment was significantly higher than that before treatment（ P 〈0.01）,and the difference of which in control group between before and after treatment was not statistically significant（ P 〉0.05）.The differences of the plasma levels of testosterone between two groups were not statistically significant before and after treatment（ P 〉0.05）.Conclusions： Liraglutide can effectively reduce the blood glucose,improve the function of pancreas islet β-cells,and enhance the plasma level of testosterone in T2DM patients complicated with obesity or overweight.

关 键 词：2型糖尿病 利拉鲁肽 睾酮 肥胖 超重 

分 类 号：R587.1[医药卫生—内分泌]