Gender Affects the Median Effective Dose and 95% Effective Dose of Oxycodone for Blunting the Hemodynamic Response to Tracheal Intubation in Narcotic-Naive Adult Patients  

作　　者：Xian-Hui Kang Fang-Ping Bao Hong-Gang Zhang Dan-Jun Yu Ke Ha Qing Xie Sheng-Mei Zhu 

机构地区：[1]Department of Anesthesiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China [2]Department of Anesthesiology, Changxing Hospital of Traditional Chinese Medicine, Changxing County, Huzhou, Zhejiang 313100, China

出　　处：《Chinese Medical Journal》2018年第16期1958-1963,共6页中华医学杂志（英文版）

摘　　要：Background： Intravenous （IV） oxycodone has been used at induction to prevent an intubation reaction. The aims of the current study were to calculate the median effective dose （ED50） and the 95% effective dose （ED95） of an IV bolus ofoxycodone that blunts the hemodynamic response to tracheal intubation with propofol according to gender and to observe the adverse events of induction-dose oxycodone. Methods： Adult patients who required general anesthesia and tracheal intubation were enrolled. Tracheal intubation was performed using unified TD-C-IV video laryngoscopy and an ordinary common endotracheal tube. Dixon＇s up-and-down method was used to obtain ED50, data for women and men separately. The initial dose of oxycodone was 0.2 mg/kg for women and 0.3 mg/kg for men （step size was 0.01 mg/kg）. Next, a dose-response curve from the probit analysis was generated to determine the ED50 and ED95 to blunt the intubation reaction in female and male patients. Adverse events following oxycodone injection were observed for 5 ,in before propofol injection. Results： Sixty-three patients were analyzed, including 29 females and 34 males. According to the probit analysis, the ED50, and ED95 of oxycodone required to blunt the intubation reaction in women were 0.254 mg/kg （95% confidence interval [CI], 0.220-0.328 mg/kg） and 0.357 mg/kg （95% （21, 0.297-2.563 mg/kg）, respectively. In men, the ED50 and ED95 were 0.324 mg/kg （95% CL 0.274-0.381 mg/kg） and 0.454 mg/kg （95% CI, 0.384-2.862 mg/kg）, respectively. Men required 28% more oxycodone than women for induction （P 〈 0.01 ）. The most common adverse events were dizziness （87.3%）, vertigo （66.7%）, sedation （74.6%）, and respiratory depression （66.7%）. Conclusions： Oxycodone can be used for induction to prevent intubation reactions. Gender affected the ED50 and ED95 ofoxycodone for blunting the tracheal intuhation reaction.Background： Intravenous （IV） oxycodone has been used at induction to prevent an intubation reaction. The aims of the current study were to calculate the median effective dose （ED50） and the 95% effective dose （ED95） of an IV bolus ofoxycodone that blunts the hemodynamic response to tracheal intubation with propofol according to gender and to observe the adverse events of induction-dose oxycodone. Methods： Adult patients who required general anesthesia and tracheal intubation were enrolled. Tracheal intubation was performed using unified TD-C-IV video laryngoscopy and an ordinary common endotracheal tube. Dixon＇s up-and-down method was used to obtain ED50, data for women and men separately. The initial dose of oxycodone was 0.2 mg/kg for women and 0.3 mg/kg for men （step size was 0.01 mg/kg）. Next, a dose-response curve from the probit analysis was generated to determine the ED50 and ED95 to blunt the intubation reaction in female and male patients. Adverse events following oxycodone injection were observed for 5 ,in before propofol injection. Results： Sixty-three patients were analyzed, including 29 females and 34 males. According to the probit analysis, the ED50, and ED95 of oxycodone required to blunt the intubation reaction in women were 0.254 mg/kg （95% confidence interval [CI], 0.220-0.328 mg/kg） and 0.357 mg/kg （95% （21, 0.297-2.563 mg/kg）, respectively. In men, the ED50 and ED95 were 0.324 mg/kg （95% CL 0.274-0.381 mg/kg） and 0.454 mg/kg （95% CI, 0.384-2.862 mg/kg）, respectively. Men required 28% more oxycodone than women for induction （P 〈 0.01 ）. The most common adverse events were dizziness （87.3%）, vertigo （66.7%）, sedation （74.6%）, and respiratory depression （66.7%）. Conclusions： Oxycodone can be used for induction to prevent intubation reactions. Gender affected the ED50 and ED95 ofoxycodone for blunting the tracheal intuhation reaction.

关 键 词：Adverse Events HEMODYNAMICS Induction INTUBATION OXYCODONE 

分 类 号：R472.9[医药卫生—护理学]