PLGA药物传递系统在女性乳腺癌治疗中的应用  

Applications of PLGA-based drug delivery system in therapy of female breast cancer

作　　者：余璇 王萌[1] YU Xuan;WANG Meng(Institute of Traditional Chinese Medicine,Tianfin University of Traditional Chinese Medicine,Tianjin 300193,China)

机构地区：[1]天津中医药大学中医药研究院,天津300193

出　　处：《中国新药杂志》2018年第15期1753-1761,共9页Chinese Journal of New Drugs

摘　　要：乳腺癌是女性最常见的恶性肿瘤,传统的治疗方法虽然有效,但也存在很多不良反应,纳米制剂因其独特的物理化学性质,良好的靶向性和较小的不良反应为治疗乳腺癌提供了新的思路,并成为抗癌的有效工具。本文结合被动靶向机制、主动靶向机制和物理化学靶向机制,对基于PLGA的纳米载药系统进行介绍,并综述了近年来该类型的纳米制剂在乳腺癌治疗中的研究进展。Breast cancer is a high incidence disease among women. The clinical therapeutic methods are effective,but have many adverse drug reactions. Nanoparticle is considered as a new treatment strategy with its unique physical and chemical properties,better targeting effect and less toxicity. The review mainly introduces PLGA-based nano-drug delivery systems which base on passive targeting mechanism,active targeting mechanism and physicochemical targeting mechanism. Recent research developments and clinical application of PLGA-based nano-drug delivery systems for treating breast cancer are also reviewed.

关 键 词：女性乳腺癌 聚乳酸聚乙醇酸 纳米技术 

分 类 号：R943[医药卫生—药剂学]