复方黄柏液涂剂治疗糖尿病足溃疡的有效性和安全性Meta分析  

Efficacy and safety of compound Cortex Phellodendri Liquid for diabetic foot ulcer: a Meta-analysis

作　　者：王宁[1] 鞠上[2] 杨博华[2] 王刚[2] 连晓彤 高瑜 张晓福 曹欣[1] 闫程程 姚丽丽 李荣荣 张定坤 WANG Ning;JU Shang;YANG Bo-hua;WANG Gang;LIAN Xiao-tong;GAO Yu;ZHANG Xiao-fu;CAO Xin;YAN Cheng-cheng;YAO Li-li;LI Rong-rong;ZHANG Ding-kun(First Affiliated Hospital of Beijing University of Chinese Traditional Medicine,Beijing 100029,China;Department of Peripheral Vascular,Dongzhimen Hospital,Beijing University of Chinese Traditional Medicine,Beijing 100700,China;Surgical Department of Nanyuan Hospital,Fengtai District,Beijing 100076,China;ICU of Rizhao Central Hospital,Rizhao 276800,China)

机构地区：[1]北京中医药大学第一临床医学院,北京100029 [2]北京中医药大学东直门医院周围血管科,北京100700 [3]北京市丰台区南苑医院外科,北京100076 [4]山东省日照市中心医院监护室,日照276800

出　　处：《中国新药杂志》2018年第15期1771-1775,共5页Chinese Journal of New Drugs

摘　　要：目的:系统评价复方黄柏液涂剂治疗糖尿病足溃疡的有效性和安全性。方法:检索Pub Med,EMBASE,The Cochrane Library,CBM,CNKI,Wan Fang Data和VIP数据库自建库至2018年3月公开发表的文章,收集复方黄柏液涂剂治疗糖尿病足溃疡的随机对照试验(RCTs)。由2名评价者独立进行文献筛选和质量评价后,运用Rev Man 5.3软件进行Meta分析。结果:最终纳入11项RCTs,共2147例患者。结果表明,复方黄柏液涂剂有效性显著高于对照组(有效性:RR=1.28,95%CI:1.17~1.41)。6项研究报道均显示无严重不良事件与该药使用有关。结论:复方黄柏液涂剂是治疗糖尿病足溃疡有效安全的外用制剂,仍需开展更多高质量的RCT进一步验证。Objective： To conduct a meta-analysis to evaluate the clinical efficacy and safety of Compound Cortex Phellodendri Liquid for treatment of diabetic foot ulcer（DFU）. Methods： Databases including Pub Med,EMBASE,The Cochrane Library,CBM,CNKI,Wanfang and VIP data were searched to collect randomized controlled trials（RCTs） about Compound Cortex Phellodendri Liquid in the treatment of DFU from inception to March 2018. Two reviewers independently evaluated the quality of the included studies and extracted the data.Meta-analysis was systematically reviewed by using Rev Man 5. 3 statistical software. Results： A total of 11 RCTs involving 2 147 patients were included. The result of meta-analysis showed that,compared with control group,Compound Cortex Phellodendri Liquid produced a statistically significant improvement for a higher effective rate in DFU（RR = 1. 28,95% CI： 1. 17 - 1. 41）. Six trials revealed that no serious adverse event was related to the use of the drug. Conclusion： Compound Cortex Phellodendri Fluid is an effective and safe external preparation for treating DFU. More high-quality RCTs need to be carried out to confirm the present findings.

关 键 词：复方黄柏液涂剂 糖尿病足 有效性 安全性 META分析 

分 类 号：R969.3[医药卫生—药理学]