Obovatol及其衍生物:合成及药用活性研究概况  

Research overview in synthesis and pharmaceutical activities of obovatol and its derivatives

作　　者：杨春[1] 郅晓燕 曹挥[1] YANG Chun;ZHI Xiao-yan;CAO Hui(College of Agriculture,Shanxi Agricultural University,Taigu 030801,China)

机构地区：[1]山西农业大学农学院,山西太谷030801

出　　处：《中国药物化学杂志》2018年第4期323-330,共8页Chinese Journal of Medicinal Chemistry

基　　金：国家自然科学基金项目(31700300);山西农业大学科技创新基金项目(2016YJ10;2016YJ09)

摘　　要：以植物体内发现的活性次级代谢产物为先导,通过结构优化来筛选新型药用化合物已成为近年来新药创制领域的一个研究热点。Obovatol是一种源自日本厚朴(Magnolia obovata Thunb.)干皮、枝皮等部位的拥有联苯醚结构的木脂素类化合物。多年来相关研究表明,obovatol及其衍生物表现出较强的抗肿瘤、抗菌、抗炎、抗血小板凝集、抗焦虑、神经保护以及对阿兹海默症的治疗作用等多种生物活性,药用潜力十分巨大。因此,本文就obovatol及其衍生物的各种生物活性、衍生物合成、obovatol的全合成等进行系统的综述,以期为后续相关研究提供一定的参考。In recent years, structural modification based on the active secondary metabolites from plants to screen novel pharmaceutical compounds has become a research focus to develop new chemotherapeutic agents. Obovatol is an important naturally occurring lignan isolated from the stem and bark of Magnolia obovata Thunb. with the diphenyl ether structure. The related researches have shown that obovatol and its derivatives exhibit potent anti-tumor, anti-fungal, anti-inflammatory, anti-platelet aggregation, anxiolytic, neuroprotective effects and the effect on the treatment of Alzheimer＇s disease etc. over the years with the great potential pharmaceutical value. Therefore, the present review will provide a systematic coverage on recent developments of obovatol and its derivatives in regard to bioactivities, semisynthesis and total synthesis, in order to provide some reference for the following research.

关 键 词：日本厚朴 OBOVATOL 木脂素 联苯醚 药用活性 

分 类 号：I14[文学—世界文学]