丹参冻干粉针对大鼠体内硝苯地平药动学的影响  

Effect of Salvia Miltiorrhiza Lyophilized Powder Injection on in vivo nifedipine pharmacokinetics in rats

作　　者：张华[1,2,3] 邱镇 陈红[1,2] 陈卫东 ZHANG Hua;QIU Zhen;CHEN Hong;CHEN Weidong(Anhui University of Chinese Medicine,Hefei,Anhui 230012,China;Anhui Provincial Academy of Traditional Chinese Medicine/Traditional Chinese Medicine Resources Protection and Development,Hefei,Anhui 230012,China;Maanshan Seventeenth Metallurgy Hospital,Maanshan,Anhui 243000,China)

机构地区：[1]安徽中医药大学,合肥230012 [2]安徽省中医药科学院/中药资源保护与开发研究所,合肥230012 [3]马鞍山十七冶医院,安徽马鞍山243000

出　　处：《重庆医学》2018年第22期2917-2920,共4页Chongqing medicine

基　　金：安徽省重点研究与开发计划项目(1704a0802145);安徽省教育厅基金项目(2016hz23);安徽省科技专项资金项目(13Z04013)

摘　　要：目的研究丹参冻干粉针对大鼠体内硝苯地平药动学的影响。方法将24只健康大鼠(雌雄各半)分成低、中、高丹参冻干粉针组(20、40、80mg/kg)和空白对照组(生理盐水),连续7d尾静脉注射灌服10mg/kg硝苯地平,给药后0.05、0.083、0.167、0.25、0.5、0.75、1、2、4、8、12、24h由大鼠眼眦取血,采用高效液相色谱(HPLC)法测定血浆硝苯地平浓度,采用DAS2.0计算药动学参数。结果与单独灌服硝苯地平相比,大鼠连续7d尾静脉注射20、40、80mg/kg丹参冻干粉针,硝苯地平的平均驻留时间[MRT(0→∞)]分别增加51.6%(P<0.05)、102.3%(P<0.05)和73.3%(P<0.01)。结论丹参冻干粉针可减慢硝苯地平的体内消除,排泄减慢,而对其他药动学参数没有影响。Objective To study the effect of Salvia Miltiorrhiza Lyophilized Powder Injection on in vivo nifedipine pharmacokinetics in rats.Methods Twenty-four healthy rats（half male and half female）were divided into the low,medium and high doses Salvia Miltiorrhiza Lyophilized Powder Injection groups（20,40,80 mg/kg）and blank control group（physiological saline）.After 7 dtail vein injection,10 mg/kg nifedipine was given to rats by gavage.Then the eye canthus blood was taken from rats at 0.05,0.083,0.167,0.25,0.5,0.75,1,2,4,8,12,24 h.The plasma nifedipine concentration was detected by HPLC.The pharmacokinetic parameters were calculated by adopting DAS2.0.Results Compared with the nifedipine gavage alone,after the rat tail vein injection of Salvia Miltiorrhiza Lyophilized Powder Injection（20,40,80 mg/kg）for 7 d,nifedipine MRT（0→∞）was increased by 51.6%（P〈0.05）,102.3%（P〈0.05）and 73.3%（P〈0.01）respectively.Conclusion Salvia Miltiorrhiza Lyophilized Powder Injection can slow down the in vivo elimination of nifedipine,and slows down its excretion,and has no effects on other pharmacokinetic parameters.

关 键 词：丹参冻干粉针 硝苯地平片 高效液相色谱 药动学 

分 类 号：R927.2[医药卫生—药学]