CD146 is essential for PDGFRβ-induced pericyte recruitment  

作　　者：Jianan Chen Yongting LUO Hongxin Huang Shuilong Wu Jing Feng Jingjing Zhang Xiyun Yan 

机构地区：[1]Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China [2]College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China [3]Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing 100193, China [4]Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China [5]Laboratory of Developmental Biology and Regenerative Medicine, School of Medicine, South China University of Technology, Guangzhou 510006, China

出　　处：《Protein & Cell》2018年第8期743-747,共5页蛋白质与细胞（英文版）

基　　金：This work was supported by the National Basic Research Program of China （973 Programs, 2015CB553705, 2014CBA02003）, the National Natural Science Foundation of China （Grant Nos. 31370824, 31771628, 81371025, 91529306, 81371330, 91640112, 31670185, 81527805, 81671851, and 81502547）, Guangdong Natural Science Fund for Distinguished Young Scholars （2017A030306024）, and China and Novo Nordisk-CAS Research Fund （NNCAS-2015-11 ）.

摘　　要：Dear Editor, The homeostasis of the central nervous system （CNS） is regulated through the blood-brain barrier （BBB）, a protective barrier between the peripheral blood and the brain （Zhao et al., 2015）. As vascular mural cells of brain microvessels, pericytes are positioned within the neurovascular unit among endothelial cells （ECs）, astrocytes, and neurons. During the embryogenesis, pericytes are recruited to and interacts with the nascent CNS vascular ECs for BBB formation and maturation.Dear Editor, The homeostasis of the central nervous system （CNS） is regulated through the blood-brain barrier （BBB）, a protective barrier between the peripheral blood and the brain （Zhao et al., 2015）. As vascular mural cells of brain microvessels, pericytes are positioned within the neurovascular unit among endothelial cells （ECs）, astrocytes, and neurons. During the embryogenesis, pericytes are recruited to and interacts with the nascent CNS vascular ECs for BBB formation and maturation.

分 类 号：Q42[生物学—神经生物学] Q421[生物学—生理学]