和肽素、正五聚蛋白3对稳定性冠心病患者冠脉狭窄程度的评估价值  

Clinical Significance of Copeptin or Pentraxin 3 in Prognosis of Artery Stenosis Degree in Stable Coronary Artery Disease Patients

作　　者：米琼瑶 杨坚[2] 曹阳[2] 李擎[2] Mi Qiongya;Yang Jian;Cao Yang;Li Qing(School of Life Science,Shanghai University,Shanghai 200444,China;Department of Rehabilitation.Shanghai Xuhui Central Hospital/Shanghai Zhongshan-Xuhui Hospital,Fudan University/Shanghai Clinical Research Center,Chinese Academy of Sciences,Shanghai 200031.China)

机构地区：[1]上海大学生命科学学院,上海200444 [2]上海市徐汇区中心医院康复科/复旦大学附属中山徐汇医院康复科/上海市中科院临床研究中心,上海200031

出　　处：《中国细胞生物学学报》2018年第7期1202-1207,共6页Chinese Journal of Cell Biology

基　　金：上海市医学重点专科心脑血管病康复重点专科项目(批准号:ZK2015A29);国家自然科学基金(批准号:81672260)资助的课题~~

摘　　要：该文评估了和肽素(CPP)、正五聚蛋白3(PTX3)、脑钠肽(BNP)、磷酸二酯酶9A(PDE9A)与稳定性冠心病患者冠脉狭窄程度的相关性。选取58例经冠脉造影检查证实为稳定性冠心病的患者,其中,冠脉狭窄≥70%组患者30例(I组),冠脉狭窄<70%组患者28例(II组),两组病史情况无显著差异。采用ELISA法测定血浆CPP、PTX3、BNP、PDE9A浓度,运用二元Logistic回归分析CPP、PTX3、BNP、PDE9A与冠脉狭窄程度是否≥70%之间的相关性,通过ROC曲线分析CPP、PTX3、BNP、PDE9A对冠脉狭窄的预测价值。研究结果表明,I组患者血浆中CPP、PTX3的水平明显高于II组(P<0.05),而I、II两组的BNP、PDE9A血浆水平无统计学差异(P>0.05)。二元Logistic回归分析发现,血浆中CPP、PTX3的水平高低与冠脉狭窄程度是否达到70%具有相关性(P<0.05)。ROC曲线分析表明,CPP(>1.07 ng/m L)预测冠脉狭窄≥70%的敏感度为63.3%,特异性为64.3%;PTX3(>20.56ng/m L)预测冠脉狭窄≥70%的敏感度为63.3%,特异性为67.9%。综上可得,血浆中CPP、PTX3的水平对稳定性冠心病患者冠脉狭窄是否≥70%具有一定评估价值;而血浆中PDE9A、BNP的水平与稳定性冠心病患者冠脉狭窄是否≥70%是否具有评估价值依据不足。This paper investigated the clinical significance of copeptin（CPP）, pentraxin 3（PTX3）, brain natriuretic peptide（BNP） and phosphodiesterase 9 A（PDE9 A） in prognosis of stable coronary artery disease（CAD） patients＇ artery stenosis degree. A total of 58 patients with stable CAD were divided into two groups by their degree of coronary artery stenosis（group I whose coronary stenosis was ≥70%, n=30; group II whose coronary steno-sis was70%,n=28）.There was no significant differences between the two groups’medical history.Plasma CPP,PTX3,BNP and PDE9A were determined by ELISA.Using binary logistic regression to analyze the correlation.The predictive value of CPP,PTX3,BNP and PDE9A was analyzed by receiver operating characteristic（ROC）curve.Plasma levels of CPP or PTX3 in group I were significantly higher than that of group II（P0.05）,while there were no statistical significance in plasma levels of BNP or PDE9A between group I and group II.ROC curve analysis showed that the sensitivity of CPP（1.07 ng/m L）predicts the degree of coronary stenosis was 63.3%and its specificity was 64.3%,the sensitivity PTX3（20.56 ng/mL）predicts coronary stenosis was 63.3%and its specificity was67.9%.CPP or PTX3 can be used as a marker for evaluating whether the coronary stenosis was≥70%in stable CAD patients;While PDE9A or BNP is not qualified for that use in our acknowledgement.

关 键 词：稳定性冠心病 和肽素 正五聚蛋白3 磷酸二酯酶9A 脑钠肽 评估 

分 类 号：R541.4[医药卫生—心血管疾病]