盐酸替罗非班氯化钠注射液治疗急性冠脉综合征的临床疗效  

Study of the Clinical Effect of Treating Acute Coronary Syndrome with Tirofiban Hydrochloride Sodium Chloride Injection

作　　者：刘宴林 郑锦坤 徐晓梅 林丽微 黄波 阮丽英 LIU Yanlin;ZHENG Jinkun;XU Xiaomei;LIN Liwei;HUANG Bo;RUAN Liying(The Affiliated Yuebei People’s Hospital of Shantou University Medical College,Shaoguan,Guangdong 512026,China;Livzon Group Limin Pharmaceutical Factory,Shaoguan,Guangdong 512028,China)

机构地区：[1]汕头大学医学院附属粤北人民医院,广东韶关512026 [2]丽珠集团利民制药厂,广东韶关512028

出　　处：《今日药学》2018年第7期473-475,共3页Pharmacy Today

摘　　要：目的研究盐酸替罗非班氯化钠注射液治疗急性冠脉综合征的临床疗效。方法随机选取2015年1月~2017年12月期间某院接诊的急性冠脉综合征患者212例,依据患者病情和意愿分为观察组和对照组。两组患者均接受支架植入或冠脉介入术,对照组患者术后给予常规用药,观察组患者给予常规用药外,术后24 h静脉注射盐酸替罗非班氯化钠注射液治疗。观察两组患者接受治疗24 h后心肌肌钙蛋白水平,1个月后ST段回落情况、不良心血管事件发生情况及出血情况等,同时观察并记录患者用药后的满意度。结果两组患者治疗后均取得良好的治疗效果,但观察组患者的疗效显著优于对照组,差异有统计学意义(P<0.05);观察组患者皮下出血及牙龈出血等发生率稍高于对照组,但差异无统计学意义(P>0.05);观察组患者再发心血管事件发生率显著低于对照组,差异有统计学意义(P<0.05);观察组患者治疗满意度优于对照组,差异有统计学意义(P<0.05)。结论盐酸替罗非班氯化钠注射液的疗效确切,起到了控制疾病恶化的作用,值得临床推广。OBJECTIVE To study the clinical effect of treating acute coronary syndrome with tirofiban hydrochloride sodium chloride injection. METHODS From January 2016 to October 2017,212 patients with acute coronary syndromes received by a hospital were randomly divided into observation group and control group according to the patients condition and intention.The patients in the control group and the observation group were treated with stent implantation or coronary intervention.The patients in the control group were treated with conventional medication after operation,and the patients in the observation group were treated by intravenous injection of tirofiban hydrochloride sodium chloride injection 24 hours after operation.The cardiac troponin levels,ST segment depression after a month,adverse cardiovascular events and bleeding were observed after 24 hours of treatment in both groups. At the same time,the satisfaction of the patients was also observed and recorded. RESULTS Two groups of patients after treatment achieved good therapeutic effect,but the observation group patients were significantly better than the control group,and the difference was statistically significant（ P0.05）. The incidence of subcutaneous hemorrhage and gingival hemorrhage in the observation group was slightly higher than that in the control group,but the difference was not statistically significant（ P 0. 05）. The incidence of recurrent cardiovascular events in the observation group was significantly lower than that in the control group,and the difference was statistically significant（ P0.05）.The treatment satisfaction in the observation group was better than that in the control group,and the difference was statistically significant（ P0.05）. CONCLUSION The effect of tirofiban hydrochloride sodium chloride injection has played a role in controlling the deterioration of the disease and is worthy of clinical promotion.

关 键 词：盐酸替罗非班氯化钠注射液 急性冠脉综合征 临床疗效 

分 类 号：R969.4[医药卫生—药理学]