玉屏风散联合西药治疗咳嗽变异性哮喘随机对照试验的meta分析  

A meta-analysis of Yupingfeng powder in conjunction of western medicine on cough variant asthma

作　　者：高伟[1] 马利荣[1] 陈敏华[1] 李雨[1] 宿芳[1] Gao Wei;Ma Lirong;Chen Minhua;Li Yu;Su Fang(Department of Respiratory Medicine,Chaoyang District Traditional Chinese Medicine Hospital of Beijing,Beijing 100020,China)

机构地区：[1]北京市朝阳区中医医院呼吸科,100020

出　　处：《国际中医中药杂志》2018年第8期722-726,共5页International Journal of Traditional Chinese Medicine

基　　金：北京市中医管理局专项资助（JJ2016.02）;第六批全国老中医药专家学术继承工作项目（2017年）

摘　　要：目的 系统评价玉屏风散联合西药治疗咳嗽变异性哮喘（cough variant asthma, CVA）的临床疗效及安全性。方法 计算机检索中国期刊全文数据库（CNKI）、中文科技期刊数据库（重庆维普）、中国学术期刊数据库（万方数据）、PubMed，各库建库至2017年10月31日的有关玉屏风散治疗CVA的RCT研究，采用改良Jadad评分量表评价研究质量并提取数据，采用Revman 5.3软件进行meta分析。结果 共纳入文献15篇，受试者1 318例。Meta分析结果提示，与单纯西药比较，联用玉屏风散可显著提高CVA患者的疗效[OR＝3.45，95% CI（2.38～5.02），P＜0.01]，降低CVA患者的复发率[OR＝0.25，95% CI （0.16～0.38），P＜0.01]，且未增加不良反应发生率[OR＝0.70，95% CI（0.34～1.46），P＝0.35]。结论 玉屏风散联合西药可能有助于提高CVA疗效，降低复发率，但尚需更多高质量RCT结果支持。Objective To evaluate the efficacy and safety of Yupingfeng powder in conjunction treatment of western medicine on cough variant asthma （CVA）. Methods We searched CNKI, Wanfang database, VIP database and PubMed through computer from the database building to October 31st 2017. The randomized controlled trails （RCT） with the comparison in the treatment of CVA with Yupingfeng powder and western medicinal were identified and included. The quality of RCTs was assessed by Jadad scores, and meta-analyses were performed by Review Manager 5.3 software. Results Totally 15 RCTs involving 1 318 patients were included into the study, which all belonged to the low methodological quality. The meta-analysis results showed that compared with the western medicine alone, the treatment in conjunction of Yupingfeng powder can significantly improve the clinical effective rate [OR=3.45, 95% CI （2.38-5.02）, P〈0.01], reduce the recurrence rate [OR=0.25, 95% CI （0.16-0.38）, P〈0.01]. There were no statistical significant differences with untoward effect between above two treatment groups [OR=0.70, 95% CI （0.34-1.46）, P=0.35]. Conclusions The Yupingfeng powder combined with the routine therapy may improve the clinical effective rate, and reduce the recurrence rate for CVA patients. However, we need more high-quality RCTs to comfirm such results.

关 键 词：玉屏风散 咳嗽变异性哮喘 随机对照试验 META分析 

分 类 号：R562.25[医药卫生—呼吸系统]