超声辅助合成5-亚苄基(硫代)巴比妥酸衍生物  

Synthesis of 5-Aromethylene Barbituric Acid Derivatives via Ultrasonic Irradiation

作　　者：吴小云 龚维 杜莹 陈卓 尹晓刚 WU Xiaoyun;GONG Wei;DU Ying;CHEN Zhuo;YIN Xiaogang(Key Laboratory of Functional Materials Chemistry of Guizhou Province,School of Chemistry and Materials Science,Guizhou Normal University,Guiyang,Guizhou 550001,China)

机构地区：[1]贵州师范大学化学与材料科学学院,贵州省功能材料化学重点实验室,贵州贵阳550001

出　　处：《化学世界》2018年第8期475-480,共6页Chemical World

基　　金：贵州省科技合作(No.黔科合LH字[2016]7218);国家自然基金(No.21362006);贵州省科技创新人才团队建设(No.黔科合人才团队[2014]4006号)资助项目

摘　　要：以蒙脱土负载碘单质作为催化剂,在超声波辐射下合成5-亚苄基(硫代)巴比妥酸衍生物,可获得良好的催化效果。对催化条件进行优选并进一步研究反应溶剂、时间、温度及原料物质的量比对产率的影响。所得最佳反应条件为:以乙醇为溶剂,反应温度为50℃、时间10min、芳香醛(1a)∶(硫代)巴比妥酸(2)为1.1∶1.0(物质的量比)。产率为82.8%~99.2%。所得5-亚苄基(硫代)巴比妥酸衍生物3a^3l通过熔点、红外、核磁进行表征。The synthesis of 5-benzylidene（thio）barbituric acid derivatives via ultrasonic irradiation using iodine as catalyst is reported with good catalytic effect.The catalytic conditions were optimized and the effect of the solvent,time,and molar ratio of starting materials were investigated.The optimum reaction conditions are as follows：ethanol as the solvent,reaction temperature：50℃,ultrasonic time：10 min,the molar ratio of starting materials of aromatic aldehyde and（thio）barbituric acid（1 a∶2）：1.1∶1.The yields ranged from 82.8%to 99.2% and the producted were characterized by IR and NMR.

关 键 词：蒙脱土负载 碘 超声辐射 5-亚苄基(硫代)巴比妥酸 

分 类 号：TQ254[化学工程—有机化工]