职业卫生生物监测方法检出限和定量限计算方法探讨  

Discussion on calculation method of detection limit and quantitative limit of occupational health biological monitoring method

作　　者：崔师伟[1] 闫慧芳[1] Cui Shiwei;Yan Huifang(National lnstithue of Occupational Health and Poison Control,Chinese Center for Disease Control and Prevetion,Beijing 100050,China)

机构地区：[1]中国疾病预防控制中心职业卫生与中毒控制所,北京100050

出　　处：《中华劳动卫生职业病杂志》2018年第7期542-545,共4页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：国家科技支撑计划项目（2014BAI12B00）;公益性行业科研专项项目（201402021）

摘　　要：目的探讨职业卫生生物监测方法检出限和定量限的计算方法。方法通过IUPAC、NIOSH、OSHA三种不同方法分别计算苯乙醛酸和苯乙醇酸的检出限和定量限。结果采用IUPAC、NIOSH、OSHA三种不同方法计算的苯乙醛酸和苯乙醇酸的检出限和定量限各不相同。结论计算职业卫生生物监测方法检出限和定量限时，为保证检出限附近的检出率及定量限附近有75％以上的回收率应采用标准曲线法，通过一系列浓度加标的方式来计算检出限和定量限。Objective To discuss calculation method of detection limit and quantitative limit of occupational health biological monitoring. Methods The detection limit and the quantitative limit of phenyl glyoxylic acid and Mandelic acid were calculated by using three different methods of IUPAC, NIOSH and OSHA respectively. Results The IUPAC, NIOSH and OSHA methods were used to calculate the detection limit and the quantitative limit of the phenyl glyoxylic acid and Mandelic acid, and the resuhs are different. Conclusion To calculate the detection limit and quantitative limit of occupational health biological monitoring methods, the standard curve method is adopted to ensure that the rate of detection in the vicinity of detection limit and more than 75% of the quantitative limits are used.

关 键 词：苯乙醛酸 苯乙醇酸 检出限 定量限 

分 类 号：R134.4[医药卫生—劳动卫生]