Notch通路在骨疾病领域的研究进展  

Research progress of notch pathway in bone diseases

作　　者：张一奇[1] 刘子云[1] 付勤[1] ZHANG Yi-qi;LIU Zi-yun;FU Qin(Department of Orthopedics,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院第一骨科,辽宁沈阳110004

出　　处：《解剖科学进展》2018年第4期411-414,共4页Progress of Anatomical Sciences

基　　金：国家自然科学基金(81370981)

摘　　要：Notch通路是一条在物种进化过程中高度保守的信号通路,在人体内多个系统中均有表达。Notch通路对骨骼系统产生重要影响,该通路在骨质疏松、骨性关节炎及骨肿瘤等疾病中均有表达,Notch信号通路可为治疗相关疾病提供新的靶点。Notch pathway is a highly conserved signal pathway during species evolution, which is expressed in many systems in human body. Notch pathway has been proved to have an important impact on the skeletal system, a large number of experiments show that the Notch pathway in osteoporosis, osteoarthritis, bone tumors and other diseases has been expressed, with the deepening of research, Notch signaling pathway can become a new target for the treatment of related diseases.

关 键 词：破骨细胞 骨质疏松症 NOTCH 结构域 胚胎干细胞 组蛋白修饰 

分 类 号：R681[医药卫生—骨科学]