miRNA与心血管疾病关系的研究进展  

The progress between miRNA and cardiovascular diseases

作　　者：于佳慧 祝旭东 李菁瑗 晏珊[3] 郝丽英[3] Jia-hui;ZHU Xu-dong;LI Jing-yuan;YAN Shan;HAO Li-ying(The Second Clinical Department;The Second Clinieal College;The Drug Toxicology Department of College of Pharmacy China Medieal University,Shenyang 110122,China)

机构地区：[1]中国医科大学临床二系,沈阳110122 [2]中国医科大学第二临床学院,沈阳110122 [3]中国医科大学药学院药物毒理教研室,沈阳110122

出　　处：《解剖科学进展》2018年第4期420-423,427,共5页Progress of Anatomical Sciences

基　　金：国家自然科学基金(31471091);国家级大学生创新训练计划项目(201610159052);辽宁省大学生创新训练计划项目(2015048)

摘　　要：miRNA是一类内源性非编码小RNA,通过影响m RNA和蛋白质来调控基因的表达。miRNA与心血管疾病之间有很大的联系,如与血管形成、血管衰老、心肌纤维化、心肌肥大、动脉粥样硬化和冠心病等。还可作为一种生物标记物,为疾病诊断与治疗提供新依据。miRNA is a group of internal noncoding small RNA, regulates the expression of genes by influencing mRNA and protein, miRNA has a very close connection with cardiovascular diseases; related to angiogenesis, vascular aging, myocardial fibrosis, myocardial hypertrophy, atherosclerosis and coronary disease. Moreover, it is also a kind of biology marker for disease diagnosis and treatment.

关 键 词：心血管疾病 心肌纤维化 心肌肥大 MIRNA 研究进展 

分 类 号：R541[医药卫生—心血管疾病]