化痰祛瘀汤对冠心病稳定性心绞痛患者血清hs-CRP、TNF-α、IL-6的影响及疗效观察  

Effect of Huatan Quyu decoction on serum high-sensitivity C-reactive protein,tumor necrosis factor-α,and interleukin-6 in patients with stable angina and its clinical efficacy

作　　者：胡黎文 李思晴 胡雪松[1] 杨德钱 赵凤林 HU Li-wen;LI Si-qing;HU Xue-song;YANG De-qian;ZHAO Feng-lin(Hunan University of Chinese Medicine,Changsha 410208,Hunan,China;Dianjiang Hospital of Traditional Chinese Medicine,Chongqing 408300,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]重庆市垫江县中医院,重庆垫江408300

出　　处：《湖南中医杂志》2018年第7期1-4,共4页Hunan Journal of Traditional Chinese Medicine

基　　金：重庆市垫江县科学技术委员会资助项目(编号:djkjxm2016jsyfysfyy044);全国基层名老中医专家传承工作室支持项目(国中药办人教发[2015]25号)

摘　　要：目的:探讨化痰祛瘀汤对冠心病稳定性心绞痛痰瘀互结证患者血清hs-CRP、TNF-α、IL-6的影响及疗效观察。方法:将冠心病稳定性心绞痛(SCAD)痰瘀互结证患者60例随机分成2组各30例,2组均给予西医常规治疗,治疗组加用化痰祛瘀汤治疗。2组疗程均为8周,比较2组综合疗效及中医证候疗效及治疗前后hs-CRP、TNF-α和IL-6水平的变化。结果:治疗组综合疗效和中医证候疗效明显高于对照组,差异均有统计学意义(P<0.05);2组hs-CRP、TNF-α、IL-6水平治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P<0.01,P<0.05)。结论:化痰祛瘀汤治疗冠心病稳定性心绞痛痰瘀互结证有较好的疗效性及安全性,同时可以降低hs-CRP、TNF-α、IL-6等炎症因子水平,提高冠状动脉粥样斑块的稳定性,保护血管内皮。Objective： To investigate the effect of Huatan Quyu decoction on serum high-sensitivity C-reactive protein（hs-CRP）,tumor necrosis factor-α（TNF-α）,and interleukin-6（IL-6） in patients with stable angina and its clinical efficacy. Methods： A total of 60 stable angina patients with intermingled phlegm and blood stasis were randomly divided into treatment group and control group,with 30 patients in each group. Both groups were given conventional Western medicine treatment,and the patients in the treatment group were given Huatan Quyu decoction in addition. The course of treatment was 8 weeks for both groups,and the two groups were compared in terms of overall response,the clinical outcome of traditional Chinese medicine（TCM） syndrome,and changes in serum levels of hs-CRP,TNF-α,and IL-6 after treatment. Results： The treatment group had significantly better overall response and clinical outcome of TCM syndrome than the control group（P〈0.05）. Both groups had significant changes in the serum levels of hs-CRP,TNF-α,and IL-6 after treatment,and there were significant differences between the two groups after treatment（P〈0.01 or P〈0.05）. Conclusion： Huatan Quyu decoction has good clinical efficacy and safety in the treatment of stable angina with intermingled phlegm and blood stasis and can reduce the levels of inflammatory factors hs-CRP,TNF-α,and IL-6,improve the stability of coronary atheromatous plaque,and protect the vascular endothelium.

关 键 词：冠心病稳定性心绞痛 痰瘀互结证 炎症因子 化痰祛瘀汤 

分 类 号：R259.414[医药卫生—中西医结合]