西格列汀相关性急性胰腺炎的文献分析  

Literature Review of Sitagliptin-related Acute Pancreatitis

作　　者：陈丽凤 王琦[1] 黄秋波 Chen Lifeng;Wang Qi;Huang Qiubo(Department of Pharmacy, No. 180 Hospital of PLA, Quanzhou 362000, Fujian, China)

机构地区：[1]解放军第180医院药学科,福建泉州362000

出　　处：《药物流行病学杂志》2018年第8期556-559,共4页Chinese Journal of Pharmacoepidemiology

摘　　要：目的:探讨西格列汀相关性急性胰腺炎的发生规律和特点,为临床安全用药提供参考。方法:检索1978年1月~2017年8月国内外学术期刊关于西格列汀相关性急性胰腺炎的个例报道,并进行文献的筛选对纳入分析的病例患者性别、年龄、人种、原患疾病,用药剂量、治疗时间、临床表现、转归、严重程度、伴发疾病、合并用药及胰腺炎病史等资料进行信息整理和统计分析。结果:共检索到8篇文献,病例数11例,其中女性7例,男性4例,50~60岁患者8例,占72.73%。白种人居多。11例患者中,10例患者在治疗一年内出现;剂量、治疗时间及胰腺炎病史与急性胰腺炎的发生关系不大,但治疗时间与严重程度呈正相关;经停药及对症治疗,大部分患者好转出院,其中1例死亡。结论:西格列汀相关性急性胰腺炎较少见,但病情可能很严重。临床上要关注患者的年龄、合并疾病及用药,特别是女性、50~60岁、伴发高血压、高脂血症、联合他汀类降脂药的患者,应密切监护患者的症状,尤其在治疗一年内,以便尽早辨别急性胰腺炎的发生。Objective： To explore the general patterns and characteristics of sitagliptin-related acute pancreatitis and provide a reference for clinical medication safety. Methods： Case reports of sitagliptin-related acute pancreatitis were searched from domestic and foreign academic journals from 1978 to August 2017. Then literatures were screened as well as the extraction. Information such as gender,age,race,primary disease,dosage,course of the treatment,clinical feature,outcome,severity,associated disease,combined medication and history of pancreatitis were collected and statistically analyzed. Results： A total of 8 literatures were retrieved which included 11 cases. Among them,7 cases were female and 4 cases were male. Patients in 50 to 60 years old were 8 cases,accounting for 72. 73%. Caucasian patients were more. Of all11 patients,10 patients developed within one year of treatment. Dose,treatment time and history of pancreatitis had little to do with acute pancreatitis. But treatment time was positively correlated with severity. After withdrawal and symptomatic treatment,most patients improved to discharge,except one died. Conclusion： Sitagliptin-related acute pancreatitis was rare,but could be severe. Doctors should pay attention to patients＇ age,comorbidities and combined medication in clinical,especially women,50 to 60 years old,accompanied by hypertension,hyperlipidemia,or combined with statins lipid-lowering drugs. Patients＇ symptoms should be monitored closely within one year of treatment in order to promptly identify acute pancreatitis.

关 键 词：西格列汀 急性胰腺炎 药品不良反应 

分 类 号：R977.15[医药卫生—药品]