脑红蛋白在中枢神经系统损伤中的保护作用研究进展  

Recent advance in neuroglobin in central nervous system injury

作　　者：蔡瀚培 郑树法[1] 康德智[1] Cai Hanpei;Zheng Shufa;Kang Dezhi(Department of Neurosurgery,First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China)

机构地区：[1]福建医科大学附属第一医院神经外科,福州350000

出　　处：《中华神经医学杂志》2018年第8期847-850,共4页Chinese Journal of Neuromedicine

摘　　要：脑红蛋白（Ngb）作为一类新发现的携氧蛋白，主要以单体形式存在于神经细胞中，与脑组织氧供应密切相关。由中枢神经系统损伤引起的神经元凋亡与坏死，加重了脑组织缺血缺氧的程度，从而进一步诱导Ngb的高度表达。而Ngb作为氧感受器和携氧蛋白，在缺血缺氧条件下能够发挥内源性神经保护作用，可降低缺血缺氧性脑损伤的程度。本文现围绕Ngb的生物学特性及其在各类中枢神经系统损伤中的神经保护作用综述如下。As a newly discovered type of oxygen-carrying protein, neuroglobin（Ngb） is mainly presented in neurons in the form of monomers, which is closely related to oxygen supply in brain tissues. Neuronal apoptosis and necrosis caused by central nervous system injury aggravate the degrees of cerebral ischemia and hypoxia, and further induce the Ngb high expression, thus exerting a significant neuroprotective effect. As oxygen receptor and oxygen-carrying protein, Ngb can exert endogenous neuroprotective effects under hypoxic conditions and reduce the degree of hypoxic-ischemic brain damage. In this paper, we summarize the structure and fimction of Ngb, and explore the expression changes and mechanism of Ngb in various types of central nervous system injury.

关 键 词：脑红蛋白 中枢神经系统损伤 神经保护 

分 类 号：R651.1[医药卫生—外科学]