Lipophagy is essential for lipid metabolism in fish  

作　　者：Jing wang Si-Lan Han Ling-Yu Li Dong-Liang Lu Samwel Mchele Limbu Dong-Liang Li Mei-Ling Zhang Zhen-Yu Du 

机构地区：[1]Laboratory of Aquaculture Nutrition and Environmental Health(LANEH),School of Life Sciences,East China Normal University, Shanghai 200241. China [2]Department of Aquatic Sciences and Fisheries Technology,University of Dar es Salaam,Dares Salaam, Tanzania

出　　处：《Science Bulletin》2018年第14期879-882,共4页科学通报（英文版）

基　　金：supported by the National Basic Research Program of China(2014CB138603)

摘　　要：Lipophagy is a form of autophagy in mammals.In this cellular process,lipid droplets(LDs)are degraded through the lysosomal degradative pathway[1].During lipophagy,LDs sequestrated in autophagosomes are delivered to lysosomes,which fuse to form autophagosomes and then develop into autophagolysosomes,leading to LDs degradation of[1].A number of studies have demonstrated that lipophagy play important roles in lipidLipophagy is a form of autophagy in mammals. In this cellular process, lipid droplets （LDs） are degraded through the lysosomal degradative pathway [1]. During lipophagy, LDs sequestrated in autophagosomes are delivered to lysosomes, which fuse to form autophagosomes and then develop into autophagolysosomes, lead- ing to LDs degradation of [1]. A number of studies have demon- strated that lipophagy play important roles in lipid metabolism and energy homeostasis in mammals [1-3]. However, studies about the existence and biological functions of lipophagy in other organ- isms have been very limited until now. For example, no evidence has been provided for lipophagy in fish, which is the largest popula- tion of vertebrates.

关 键 词：类脂化合物 新陈代谢 鱼 哺乳动物 生物功能 脊椎动物 ing LD 

分 类 号：S917.4[农业科学—水产科学]