Synthesis of amphiphilic poly(fluorene) derivatives for selective imaging of Staphylococcus aureus  

作　　者：Ping He Fengting Lv Libing Liu Shu Wang 

机构地区：[1]Key Laboratory of Organic Solids,Institute of Chemistry,Chinese Academy of Sciences, Beijing 100190, China [2]College of Chemistry, University of Chinese Academy of Sciences, Beijing 100049, China

出　　处：《Science Bulletin》2018年第14期900-906,共7页科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(21773268,21473220);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16020804)

摘　　要：Three amphiphilic poly（fluorene-co-phenylene） derivatives with different side chains （PFP-I, PFP-2, PFP- 3） were designed and synthesized for exploring their detection and imaging of pathogens. Upon incuba- tion with six kinds of different pathogens, it was found the three polymers could selectively interact with Staphylococcus oureus （S. aureus）. Their selective imaging towards S. aureus were thus realized. The selective imaging towards S. aureus was also confirmed even under the blend of microbes. PFP-3 shows stronger fluorescence imaging signal than PFP-1 and PFP-2. Zeta potential and isothermal titration microcalorimetry （ITC） tests demonstrated that both electrostatic interactions and hydrophobic interac- tions played important roles in the binding between PFPs and pathogens. Thus, amphiphilic PFP-3 exhi- bits great potential for specific imaging ors. aureus in a simple and rapid manner.Three amphiphilic poly(fluorene-co-phenylene) derivatives with different side chains(PFP-1, PFP-2, PFP-3) were designed and synthesized for exploring their detection and imaging of pathogens. Upon incubation with six kinds of different pathogens, it was found the three polymers could selectively interact with Staphylococcus aureus(S. aureus). Their selective imaging towards S. aureus were thus realized. The selective imaging towards S. aureus was also confirmed even under the blend of microbes. PFP-3 shows stronger fluorescence imaging signal than PFP-1 and PFP-2. Zeta potential and isothermal titration microcalorimetry(ITC) tests demonstrated that both electrostatic interactions and hydrophobic interactions played important roles in the binding between PFPs and pathogens. Thus, amphiphilic PFP-3 exhibits great potential for specific imaging of S. aureus in a simple and rapid manner.

关 键 词：Conjugated polymers Pathogens S. aureus Selective imaging 

分 类 号：O631[理学—高分子化学] R378.11[理学—化学]