核辐射对机体循环肿瘤细胞产生及基因变化影响与意义  

Nuclear radiation affecting the production of circulating tumor cells and genetic changes in the body

作　　者：刘璐[1] 李川[1] 韩涛[2] LIU Lu;LI Chuan;HAN Tao(Department of Science Training,The General Hospital of Shenyang Military Command,Shenyang 110016,China)

机构地区：[1]沈阳军区总医院科训科,辽宁沈阳110016 [2]沈阳军区总医院肿瘤科,辽宁沈阳110016

出　　处：《临床军医杂志》2018年第8期913-915,共3页Clinical Journal of Medical Officers

基　　金：全军医学科技青年培育项目计划(15QNP001);辽宁省博士科研启动基金(201601396)

摘　　要：目的探讨核辐射对机体循环肿瘤细胞产生及基因变化影响与意义。方法选取沈阳军区总医院肿瘤科2016年1—12月收治的100例肿瘤患者为研究对象。根据受核情况,将所有患者分为受核组(n=50)及无受核组(n=50)。检测两组循环肿瘤细胞(CTC)和第二代DNA测序,比较两组机体循环癌症细胞产生情况及基因变化情况。结果受核组各类型CTC检出率、第二代DNA测序变异率均高于无受核组,组间比较,差异有统计学意义(P<0.05)。结论核辐射能增加机体循环肿瘤细胞产生,促进机体基因改变,增加肿瘤发生概率。Objective To investigate the effects and significance of nuclear radiation on the production and gene changes of circulating tumor cells. Methods A retrospective study was performed on 100 cases of patients with tumor cancer who were admitted from January to December in 2016. According to the nucleation,patients were randomly divided into the nucleation group（ n = 50） and the non-nucleation group（ n = 50）. Two groups of circulating tumor cells（ CTC） and second-generation DNA sequencing were detected to compare the production and genetic changes of circulating cancer cells in the two groups. Results The CTC detection rates of the two groups were compared,and the difference was statistically significant（ P〈0. 05）. The variation rate of second generation DNA sequencing in the two groups was statistically significant（ P〈0. 05）. Conclusion Nuclear radiation can increase the production of circulating tumor cells,promote gene changes in the body,and increase the probability of tumorigenesis by radiation.

关 键 词：核辐射 肿瘤 循环肿瘤细胞 基因变化 

分 类 号：R14[医药卫生—公共卫生与预防医学]