复方参鹿颗粒联合西药对肾阳虚证再生障碍性贫血患者Treg细胞及细胞因子的影响  

Effects of Compound Shenlu Granules combined with synthetic medications on Treg cells and cytokines of aplastic anemia patients due to Kidney Yang Deficiency Pattern

作　　者：陆颖佳[1] 赵琳[1] 陈珮[1] 邱仲川[1] 黄中迪[1] 胡晓莹[1] 朱小勤[1] 瞿玮颖 LU Ying-jia;ZHAO Lin;CHEN Pei;QIU Zhong-chuan;HUANG Zhong-di;HU Xiao-ying;ZHU Xiao-qin;QU Wei-ying(Department of Hematology,Shugnang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院血液科,上海201203

出　　处：《中成药》2018年第8期1705-1710,共6页Chinese Traditional Patent Medicine

基　　金：上海市进一步加快中医药事业发展三年行动计划(ZY3-JSFC-2-1036)

摘　　要：目的考察复方参鹿颗粒联合西药对肾阳虚证再生障碍性贫血患者Treg细胞及细胞因子的影响。方法 104例患者随机分为治疗组和对照组,对照组给予西药,治疗组在对照组基础上加用复方参鹿颗粒,疗程6个月。然后,观察2组临床疗效,流式细胞术、ELISA法分别检测Treg细胞、细胞因子变化。结果治疗组临床疗效显著优于对照组(P<0.01)。治疗后,治疗组血红蛋白含有量、血小板计数均显著高于对照组(P<0.05),但2组血细胞升高程度无显著差异(P>0.05)。49例患者完成Treg细胞、细胞因子检测。与对照组比较,治疗组Treg细胞比例升高,IL-2、IL-6、IL-8、TNF-α、IFN-γ水平降低,差异均有统计学意义(P<0.05)。结论复方参鹿颗粒可改善肾阳虚证再生障碍性贫血患者临床症状,尤其是血红蛋白含有量,其机制可能与提高Treg细胞比例、降低细胞因子水平、调节免疫有关。AIM To investigate the effects of Compound Shenlu Granules combined with synthetic medications on Treg cells and cytokines of aplastic anemia patients due to Kidney Yang Deficiency Pattern. METHODS One hundred and four patients randomly divided into control group and treatment group went on 6-month interventions of synthetic medications,and a combination therapy of Compound Shenlu Granules and synthetic medications,respectively,after which the clinical efficacies were assessed,and the changes of Treg cells and cytokines were detected by flow cytometry and ELISA,respectively. RESULTS Better clinical efficacy（ P〈0. 01）,and markedly higher post-treatment hemoglobin content and platelet count（ P〈0. 05） were observed in the treatment group than the control group,but there existed no significant difference in the degree of blood cells increase between the two groups（ P〈0. 05）. Forth-nine patients finished the detection of Treg cells and cytokines. Statistically different increase in ratio of Treg cells and decrease in levels of IL-2,IL-6,IL-8,TNF-α,and IFN-γ were observable in the treatment group in contrast to the control group（ P〈0. 05）. CONCLUSION Compound Shenlu Granules can improve the clinical symptoms of aplastic anemia patients due to Kidney Yang Deficiency Pattern,especially for hemoglobin content,whose mechanisms may be related to increasing ratio of Treg cells,decreasing levels of cytokines and regulating immune.

关 键 词：复方参鹿颗粒 西药 再生障碍性贫血 肾阳虚证 TREG细胞 细胞因子 

分 类 号：R287[医药卫生—中药学]