酚妥拉明联合垂体后叶素在支气管扩张咯血治疗中的应用及效果探究  

Application and effect exploration of Phentolamine combined with pituitrin in the treatment of bronchiectasis associated with hemoptysis

作　　者：吴海华[1] WU Hai-hua(Respiratory Department of Internal Medicine,New Rongqi Hospital,Foshan 528300,China)

机构地区：[1]新容奇医院呼吸内科,528300

出　　处：《中国现代药物应用》2018年第16期10-12,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨酚妥拉明联合垂体后叶素在支气管扩张咯血治疗中的临床效果。方法 90例支气管扩张咯血患者,根据治疗方法不同分为对照组和观察组,各45例。对照组给予单一酚妥拉明治疗,观察组则给予酚妥拉明联合垂体后叶素治疗。比较两组治疗效果、咯血停止时间、呼吸困难缓解时间、四肢皮温恢复时间、治疗前后患者肺动脉压和生活质量、药物不良反应发生情况。结果观察组治疗总有效率为97.78%,高于对照组的68.89%,差异有统计学意义(P<0.05)。治疗前两组肺动脉压和生活质量评分比较差异无统计学意义(P>0.05);治疗后观察组肺动脉压和生活质量评分均优于对照组,差异有统计学意义(P<0.05)。观察组咯血停止时间、呼吸困难缓解时间、四肢皮温恢复时间均短于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论酚妥拉明联合垂体后叶素治疗支气管扩张咯血的应用效果确切,可有效控制出血,加速症状消失,降低肺动脉压,提高生活质量,无严重不良反应,安全有效,值得推广应用。Objective To investigate the clinical effect of Phentolamine combined with pituitrin in the treatment of bronchiectasis associated with hemoptysis. Methods A total of 90 bronchiectasis patients associated with hemoptysis were divided into control group and observation group according to the different methods of treatment, 45 cases in each group. The control group was only treated with Phentolamine, the observation group was treated with Phentolamine combined with pituitrin. The treatment effect, the cessation time of hemoptysis, the remission time of dyspnea, the recovery time of the skin temperature of the extremities, the pulmonary arterial pressure and the quality of life before and after treatment, the occurrence of adverse drug reactions between the two groups were compared. Results The total effective rate of the observation group was 97.78%, which was significantly higher than 68.89% of the control group, the difference was statistically significant（P0.05）. There were no significant differences in the pulmonary arterial pressure and quality of life score between the two groups before treatment（P0.05）, and the scores of pulmonary arterial pressure and quality of life in the observation group after treatment were significantly better than those in the control group, and the differences were statistically significant（P0.05）. The cessation time of hemoptysis, the remission time of dyspnea, the recovery time of the skin temperature of the extremities in the observation group were significantly shorter than those of the control group, the differences were statistically significant（P0.05）. There was no significant difference in the incidence of adverse reactions between the two groups（P0.05）. Conclusion The application effect of Phentolamine combined with pituitrin in the treatment of bronchiectasis associated with hemoptysis is effective. It can effectively control hemorrhage, accelerate the symptom disappearance, reduce the pressure of pulmonary artery, improve the quality of life, and has n

关 键 词：酚妥拉明 垂体后叶素 支气管扩张咯血 效果 

分 类 号：R562.22[医药卫生—呼吸系统]