阿托伐他汀治疗老老年2型糖尿病的临床观察  

Clinical research of atorvastatin in very elderly patients with diabetes

作　　者：王淑丽[1] 田涛[1] 周东浩[1] 王世明[1] 薛燕[2] 孙宗钦[3] WANG Shuli;TIAN Tao;ZHOU Donghao;WANG Shiming;XUE Yan;SUN Zongqin(Linyi City people＇s hospital,Shandong 276003,China)

机构地区：[1]山东省临沂市人民医院老年病科,276003 [2]山东省临沂市人民医院超声科,276003 [3]山东省临沂市人民医院检验科,276003

出　　处：《中国老年保健医学》2018年第4期52-54,共3页Chinese Journal of Geriatric Care

摘　　要：目的探讨阿托伐他汀对老老年2型糖尿病患者的临床疗效。方法将老老年2型糖尿病患者,随机分为治疗组和对照组,对照组只给予门冬胰岛素常规降糖治疗,治疗组在对照组基础上给予口服阿托伐他汀治疗,分别于治疗前及治疗6个月后测定颈动脉IMT的变化,并抽血检测糖化血红蛋白、血脂、Hcy、肌酐、尿素氮等,并计算肾小球滤过率。结果治疗前后两组患者糖化血红蛋白都有显著下降(P<0.05),治疗组治疗6个月后IMT,Hcy,TC,TG和LDL水平明显下降(P<0.05),肾小球滤过率治疗后无统计学差异(P>0.05)。而对照组治疗前后除糖化血红蛋白外的其他各项指标均无明显变化。结论阿托伐他汀能显著降低老老年2型糖尿病患者血脂、Hcy水平,并能延缓颈动脉粥样硬化的进展。Objective To evaluate the effect of atorvastatin on carotid atherosclerotic plaques in very elderly patients with diabetes. Methods The very elderly patients with diabetes were divided into two groups. Patients in treatment group were administered with atorvastatin and insulin. Patients in control group were not administered with atorvastatin. Glycosylated hemoglobin,total cholesterol,triglyceride,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,homocysteine,glomerular filtration rate were measured before and 6 months after treatment. At the same period,carotid intima-media thickness was calculated. Results Compared with the data before treatment,the level of glycosylated hemoglobin decreased in two groups（P〈0. 05）; and the level of total cholesterol,triglyceride,low-density lipoprotein cholesterol,homocysteine,carotid intima-media thickness decreased in treatment group at 6 months after treatment（P〈0. 05）. Conclusion Atorvastatin can improve atherosclerosis in very elderly patients with diabetes.

关 键 词：阿托伐他汀 老老年糖尿病 颈动脉粥样硬化 

分 类 号：R587.1[医药卫生—内分泌]