量子点纳米荧光探针在生物研究中的应用  

The application of quantum dots as fluorescence probes in biology research

作　　者：赵美霞[1] 张志强[1] 乔路路 ZHAO Meixia;ZHANG Zhiqiang;QIAO Lulu(Key Laboratory of Natural Medicine and Immune Engineering,Henan University,Kaifeng 475004,Henan,China,Henan,Chin)

机构地区：[1]河南大学天然药物与免疫工程重点实验室,河南开封475004

出　　处：《化学研究》2018年第4期422-428,共7页Chemical Research

基　　金：国家自然科学基金(21501044);河南省教育厅科学技术研究重点项目(16A150004);河南省高校科技创新人才(18HASTIT049);河南省高等学校青年骨干教师培养计划(2015GGJS-028);河南大学校特聘教授项目

摘　　要：半导体量子点是一类新型纳米材料,具有激发光谱宽而连续、发射光谱窄而对称、发光效率高、光化学稳定性好、不易光漂白、粒子尺寸不同发射光的颜色也不同、生物亲和性好等优点,可以很好地用于荧光标记,是一种具有发展潜力的荧光探针.本文对量子点的基本特性、在细胞荧光标记和成像以及在肿瘤诊断影像中的应用进展及发展前景进行了综述.Semiconductor quantum dots, a new class of nanomaterials, shows broader and continuous excitation spectrum, narrower and symmetrical emission spectra, high fluorescence efficiency, good photochemical stability, not easy to photobleaching, the different light emitted color with the change of the particle size, and good biocompatibility. So it is potential for development as fluorescent probes. This paper reviewed the basic characteristics of the quantum dots, the cell fluorescence labeling and imaging, as well as in tumor diagnostic imaging in the progress and prospects for development in the life sciences.

关 键 词：量子点 光学性质 荧光探针 生物应用 

分 类 号：Q279[生物学—细胞生物学]